Evidence map›Paper›PMID 17158406›Full record

SynthesisThe American journal of clinical nutrition2006

Iron supplementation in early childhood: health benefits and risks.

Lora L Iannotti, James M Tielsch, Maureen M Black, Robert E Black

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01758159 (The Effect of Optimized Local Food-based Complementary Feeding With or Without Iron Supplementation on Iron Status and Gut Microbiota of 1-2 Years Old Myanmar Children), which is not on this map. Cited by 101 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 12 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01758159 phase3unknown statusnot on this mapstarted 2013, after this paper: background citation

The Effect of Optimized Local Food-based Complementary Feeding With or Without Iron Supplementation on Iron Status and Gut Microbiota of 1-2 Years Old Myanmar Children

TypeinterventionalSponsorSEAMEO Regional Centre for Food and NutritionRan2013 to 2014Enrolled433ConditionsIron Deficiency, Iron Deficiency AnemiaArmsIron supplementation, CFR
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 12 syntheses or guidelines pooled it, 314 citations in OpenAlex.

  1. Vitamin C supplementation for prevention and treatment of pneumonia.The Cochrane database of systematic reviews · 2021
    Pooled it
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  5. Vitamin C supplementation for prevention and treatment of pneumonia.The Cochrane database of systematic reviews · 2020
    Pooled it
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  7. Oral iron supplements for children in malaria-endemic areas.The Cochrane database of systematic reviews · 2016
    Pooled it
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  12. A meta-analysis of pica and micronutrient status.American journal of human biology : the official journal of the Human Biology Council
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lora L IannottiDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
James M Tielsch
Maureen M Black
Robert E Black
University of Maryland, Baltimore · USJohns Hopkins University · US

Funding

ZINC AND IRON SUPPLEMENTATION: IMPACT ON DEVELOPMENTR01HD037430 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLACK, MAUREEN M. · 1999 to 2002
$1.0M
NICHD NIH HHS R01 HD037430
6 · The paper itself

Abstract

The prevalence of iron deficiency among infants and young children living in developing countries is high. Because of its chemical properties--namely, its oxidative potential--iron functions in several biological systems that are crucial to human health. Iron, which is not easily eliminated from the body, can also cause harm through oxidative stress, interference with the absorption or metabolism of other nutrients, and suppression of critical enzymatic activities. We reviewed 26 randomized controlled trials of preventive, oral iron supplementation in young children (aged 0-59 mo) living in developing countries to ascertain the associated health benefits and risks. The outcomes investigated were anemia, development, growth, morbidity, and mortality. Initial hemoglobin concentrations and iron status were considered as effect modifiers, although few studies included such subgroup analyses. Among iron-deficient or anemic children, hemoglobin concentrations were improved with iron supplementation. Reductions in cognitive and motor development deficits were observed in iron-deficient or anemic children, particularly with longer-duration, lower-dose regimens. With iron supplementation, weight gains were adversely affected in iron-replete children; the effects on height were inconclusive. Most studies found no effect on morbidity, although few had sample sizes or study designs that were adequate for drawing conclusions. In a malaria-endemic population of Zanzibar, significant increases in serious adverse events were associated with iron supplementation, whereas, in Nepal, no effects on mortality in young children were found. More research is needed in populations affected by HIV and tuberculosis. Iron supplementation in preventive programs may need to be targeted through identification of iron-deficient children.

Indexed as

Anemia, Iron-DeficiencyBody WeightChild, PreschoolDeveloping CountriesDietary SupplementsFemaleGrowthHumansInfantInfant, NewbornInfection ControlInfectionsIronIron DeficienciesMaleMorbidityIronTrace Elements

Identifiers

PMID17158406
PMCPMC3311916
OpenAlexW2096017579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.