ArticleNucleic acids research2007
Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed, 111 citations in OpenAlex.
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- DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling.Cell death & disease · 2021Article
- DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma.EBioMedicine · 2019Article
- Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration.Drug design, development and therapy · 2019Article
- Silencing miR-16 Expression Promotes Angiotensin II Stimulated Vascular Smooth Muscle Cell Growth.Cell & developmental biology · 2017Article
- Characterization and Profiling of Liver microRNAs by RNA-sequencing in Cattle Divergently Selected for Residual Feed Intake.Asian-Australasian journal of animal sciences · 2016Article
- MicroRNA expression and its association with DNA repair in preimplantation embryos.The Journal of reproduction and development · 2016Review
- XB130: A novel adaptor protein in cancer signal transduction.Biomedical reports · 2016Article
- MicroRNA-877 acts as a tumor suppressor by directly targeting eEF2K in renal cell carcinoma.Oncology letters · 2016Article
- Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep.Scientific reports · 2015Article
- Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency.Scientific reports · 2015Article
- Combined Small RNA and Degradome Sequencing Reveals Novel MiRNAs and Their Targets in the High-Yield Mutant Wheat Strain Yunong 3114.PloS one · 2015Article
- Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine.BMC systems biology · 2014Article
- Identification and profiling of microRNAs and their target genes from developing caprine skeletal Muscle.PloS one · 2014Article
- miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells.Molecular and cellular biochemistry · 2013Article
- BayMiR: inferring evidence for endogenous miRNA-induced gene repression from mRNA expression profiles.BMC genomics · 2013Article
- XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells.PloS one · 2013Article
- Insights into the regulation of human CNV-miRNAs from the view of their target genes.BMC genomics · 2012Article
- Does base-pairing strength play a role in microRNA repression?RNA (New York, N.Y.) · 2012Article
- The regulatory effect of miRNAs is a heritable genetic trait in humans.BMC genomics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are non-coding small RNAs of approximately 22 nt that regulate the gene expression by base pairing with target mRNAs, leading to mRNA cleavage or translational repression. It is currently estimated that miRNAs account for approximately 1% of predicted genes in higher eukaryotic genomes and that up to 30% of genes might be regulated by miRNAs. However, only very few miRNAs have been functionally characterized and the general functions of miRNAs are not globally studied. In this study, we systematically analyzed the expression patterns of miRNA targets using several public microarray profiles. We found that the expression levels of miRNA targets are lower in all mouse and Drosophila tissues than in the embryos. We also found miRNAs more preferentially target ubiquitously expressed genes than tissue-specifically expressed genes. These results support the current suggestion that miRNAs are likely to be largely involved in embryo development and maintaining of tissue identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.