ArticleAnnals of the rheumatic diseases2007
IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort.Scientific reports · 2016Pooled it
- Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis.Rheumatology international · 2013Pooled it
- Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2013Pooled it
- Triple immunotherapy containing telitacicept for systemic lupus erythematosus complicated by multiple autoimmune diseases: a case report.Frontiers in immunology · 2026Article
- Article
- Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis.Clinical rheumatology · 2018Article
- The Role of Long Non-coding RNAs in the Pathogenesis of RA, SLE, and SS.Frontiers in medicine · 2018Article
- Genetics of rheumatoid arthritis: what have we learned?Immunogenetics · 2011Review
- Recent advances in the genetics of systemic lupus erythematosus.Expert review of clinical immunology · 2010Review
- Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes.Genes and immunity · 2010Article
- 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population.Arthritis research & therapy · 2009Article
- Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.Arthritis research & therapy · 2009Article
- Association and expression study of PRKCH gene in a French Caucasian population with rheumatoid arthritis.Journal of clinical immunology · 2008Article
- Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.Arthritis research & therapy · 2008Review
- HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.Journal of human genetics · 2007Article
- The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study.Arthritis research & therapy · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a new genetic factor within the interferon regulatory factor 5 (IRF5) gene was demonstrated for systemic lupus erythematosus (SLE) through linkage and association: the rs2004640-T allele. IRF5 is involved in the production of rheumatoid arthritis (RA) cytokines, and SLE already shares with RA one genetic factor within the tyrosine phosphatase PTPN22 gene.
aimTo test the hypothesis that the SLE IRF5 genetic factor could also be shared with RA. PATIENTS AND
methods100 French Caucasian trio families with RA were genotyped and analysed with the transmission disequilibrium test, the frequency comparison of the transmitted and untransmitted alleles, and the genotype relative risk. 97% power was available to detect at least a trend in favour of a factor similar to that reported for SLE.
resultsThe analysis showed the absence of linkage and association globally and in "autoimmune" RA subsets, with a weak non-significant trend against the IRF5 rs20046470-T allele. Given the robustness of familial-based analysis, this slight negative trend provided strong evidence against even a weaker factor than that reported for SLE.
conclusionOur results exclude the IRF5 rs2004640-T allele as a major genetic factor for RA in this French Caucasian population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.