ArticleThe Journal of biological chemistry2007
Hormonal regulation of nuclear permeability.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Role of TRP Channels in Liver-Related Diseases.International journal of molecular sciences · 2023Review
- The Nuclear Envelope as a Regulator of Immune Cell Function.Frontiers in immunology · 2022Review
- An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.Journal of molecular and cellular cardiology · 2014Review
- The insulin receptor translocates to the nucleus to regulate cell proliferation in liver.Hepatology (Baltimore, Md.) · 2014Article
- Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Calcium signaling in synapse-to-nucleus communication.Cold Spring Harbor perspectives in biology · 2011Review
- Calcium regulation of nucleocytoplasmic transport.Protein & cell · 2011Review
- The plasmodium receptor for activated C kinase protein inhibits Ca(2+) signaling in mammalian cells.Biochemical and biophysical research communications · 2009Article
- Measuring Ca2+ influxes of TRPC1-dependent Ca2+ channels in HL-7702 cells with non-invasive micro-test technique.World journal of gastroenterology · 2009Article
- Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery.Journal of virology · 2009Article
- Phospholipase C beta 4 in mouse hepatocytes: rhythmic expression and cellular distribution.Comparative hepatology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transport into the nucleus is critical for regulation of gene transcription and other intranuclear events. Passage of molecules into the nucleus depends in part upon their size and the presence of appropriate targeting sequences. However, little is known about the effects of hormones or their second messengers on transport across the nuclear envelope. We used localized, two-photon activation of a photoactivatable green fluorescent protein to investigate whether hormones, via their second messengers, could alter nuclear permeability. Vasopressin and other hormones that increase cytosolic Ca2+ and activate protein kinase C increased permeability across the nuclear membrane of SKHep1 liver cells in a rapid unidirectional manner. An increase in cytosolic Ca2+ was both necessary and sufficient for this process. Furthermore, localized photorelease of caged Ca2+ near the nuclear envelope resulted in a local increase in nuclear permeability. Neither activation nor inhibition of protein kinase C affected nuclear permeability. These findings provide evidence that hormones linking to certain G protein-coupled receptors increase nuclear permeability via cytosolic Ca2+. Short term regulation of nuclear permeability may provide a novel mechanism by which such hormones permit transcription factors and other regulatory molecules to enter the nucleus, thereby regulating gene transcription in target cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.