ReviewSeminars in cell & developmental biology2006
Mechanism and functional significance of TRPC channel multimerization.
Review in Seminars in cell & developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Calcium imbalance drives organelle network collapse and immune remodeling: novel pathogenic mechanisms in MASLD progression.Frontiers in immunology · 2026Review
- Transient Receptor Potential Channels in the Healthy and Diseased Blood-Brain Barrier.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Review
- A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.International journal of molecular sciences · 2023Review
- The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis.Frontiers in cell and developmental biology · 2021Review
- TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells.Molecular medicine reports · 2016Article
- Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels.Pflugers Archiv : European journal of physiology · 2014Article
- Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C δ (PKCδ) and stromal interaction molecule 2 (STIM2).The Journal of biological chemistry · 2012Article
- The closing and opening of TRPC channels by Homer1 and STIM1.Acta physiologica (Oxford, England) · 2012Review
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Differential expression of TRPC channels in the left ventricle of spontaneously hypertensive rats.Molecular biology reports · 2010Article
- TRPV1 splice variants: structure and function.Frontiers in bioscience (Landmark edition) · 2010Review
- Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility.Circulation research · 2010Article
- Calcium signaling in immune cells.Nature immunology · 2009Review
- Revisiting TRPC1 and TRPC6 mechanosensitivity.Pflugers Archiv : European journal of physiology · 2008Article
- Organization and function of TRPC channelosomes.Pflugers Archiv : European journal of physiology · 2007Review
- The dynamic complexity of the TRPC1 channelosome.Channels (Austin, Tex.)Review
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
Ca(2+) signaling regulates many important physiological events within a diverse set of living organisms. In particular, sustained Ca(2+) signals play an important role in controlling cell proliferation, cell differentiation and the activation of immune cells. Two key elements for the generation of sustained Ca(2+) signals are store-operated and receptor-operated Ca(2+) channels that are activated downstream of phospholipase C (PLC) stimulation, in response to G-protein-coupled receptor or growth factor receptor stimulation. One goal of this review is to help clarify the role of canonical transient receptor potential (TRPC) proteins in the formation of native store-operated and native receptor-operated channels. Toward that end, data from studies of endogenous TRPC proteins will be reviewed in detail to highlight the strong case for the involvement of certain TRPC proteins in the formation of one subtype of store-operated channel, which exhibits a low Ca(2+)-selectivity, in contrast to the high Ca(2+)-selectivity exhibited by the CRAC subtype of store-operated channel. A second goal of this review is to highlight the growing body of evidence indicating that native store-operated and native receptor-operated channels are formed by the heteromultimerization of TRPC subunits. Furthermore, evidence will be provided to argue that some TRPC proteins are able to form multiple channel types.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.