ArticleNeuroscience2007
Integrins regulate opioid receptor signaling in trigeminal ganglion neurons.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Activation of G protein gated inwardly rectifying potassium (GIRK) channels in keratinocytes mediates peripheral kappa opioid receptor-mediated antinociception.Neuropharmacology · 2025Article
- 14-3-3γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine.Neuropharmacology · 2022Article
- Age-related changes in peripheral nociceptor function.Neuropharmacology · 2022Article
- New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies.Frontiers in immunology · 2022Article
- Oxycodone Self-Administration Induces Alterations in Expression of Integrin, Semaphorin and Ephrin Genes in the Mouse Striatum.Frontiers in psychiatry · 2018Article
- Regulation of δ Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid-Dependent 12/15-Lipoxygenase Metabolites.The Journal of pharmacology and experimental therapeutics · 2017Article
- Dual regulation of δ-opioid receptor function by arachidonic acid metabolites in rat peripheral sensory neurons.The Journal of pharmacology and experimental therapeutics · 2015Article
- Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration.British journal of pharmacology · 2015Article
- Activation of estrogen receptor α enhances bradykinin signaling in peripheral sensory neurons of female rats.The Journal of pharmacology and experimental therapeutics · 2014Article
- A role for G-proteins in directing G-protein-coupled receptor-caveolae localization.Biochemistry · 2012Article
- Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.Molecular pharmacology · 2012Article
- Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma.Journal of allergy · 2012Article
- Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo.The Journal of pharmacology and experimental therapeutics · 2011Article
- Orofacial pain.Pain · 2011Review
- Role of integrins in angiotensin II-induced proliferation of vascular smooth muscle cells.American journal of physiology. Cell physiology · 2011Article
- 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo.The Journal of pharmacology and experimental therapeutics · 2010Article
- Bradykinin B2 receptor interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells.Molecular pharmacology · 2010Article
- A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.Molecular pain · 2010Article
- Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR).Methods in molecular biology (Clifton, N.J.) · 2010Article
- Peripheral mechanisms of pain and analgesia.Brain research reviews · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The binding of integrins to the extracellular matrix results in focal organization of the cytoskeleton and the genesis of intracellular signals that regulate vital neuronal functions. Recent evidence suggests that integrins modulate G-protein-coupled receptor (GPCR) signaling in hippocampal neurons. In this study we evaluated the hypothesis that integrins regulate the mu opioid receptor in rat trigeminal ganglion neurons. For these studies, primary cultures of adult rat trigeminal ganglion neurons were used to demonstrate the colocalization of beta1 and beta3 integrins with mu opioid receptor in caveolin-1-rich membrane fractions, and at focal adhesions sites generated by integrin ligand binding. Furthermore, we show that the mu opioid receptor agonist, DAMGO ([D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin), inhibits cyclic AMP (cAMP) accumulation in response to prostaglandin E2 (PGE(2)) stimulation in bradykinin-primed, but not unprimed, cultured trigeminal ganglia neurons. Application of soluble GRGDS (Gly-Arg-Gly-Asp-Ser) peptides that bind specific integrins (i.e. RGD-binding integrins) completely abolished the DAMGO effect in bradykinin-primed trigeminal ganglia neurons, but did not alter bradykinin-mediated hydrolysis of phosphatidylinositol. Likewise, monospecific anti-beta1 and anti-beta3 integrin subunit antibodies blocked this DAMGO effect in bradykinin-primed trigeminal ganglia neurons. Indeed, application of anti-beta1 integrin subunit actually reversed DAMGO signaling, resulting in increased cAMP accumulation in these cells. This suggests that the relative amounts of specific activated integrins at focal adhesions may govern signaling by the mu opioid receptor, perhaps by altering interactions with G proteins (e.g. Galphai vs. Galphas). Collectively, these data provide the first evidence that specific integrins regulate opioid receptor signaling in sensory neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.