ArticleMechanisms of ageing and development2007
Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal.
Article in Mechanisms of ageing and development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells.Aging cell · 2025Article
- Antioxidant, antiaging and mitochondrial protective effects of JadeAging inFrontiers in pharmacology · 2025Article
- Components in SLPE Alleviate AD Model Nematodes by Up-Regulating GeneInternational journal of molecular sciences · 2024Article
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- One-day thermal regime extends the lifespan in Caenorhabditis elegans.Computational and structural biotechnology journal · 2023Article
- Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p.Bioscience of microbiota, food and health · 2022Article
- Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.Hearing research · 2021Review
- Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies.Frontiers in cell and developmental biology · 2021Review
- Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging.Antioxidants (Basel, Switzerland) · 2020Article
- Identifying longevity associated genes by integrating gene expression and curated annotations.PLoS computational biology · 2020Article
- The Lipidome Fingerprint of Longevity.Molecules (Basel, Switzerland) · 2020Review
- Review
- Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.Experimental gerontology · 2020Article
- Article
- Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in ANutrients · 2019Article
- GSTA4 mediates reduction of cisplatin ototoxicity in female mice.Nature communications · 2019Article
- The glutathione system and the related thiol network in Caenorhabditis elegans.Redox biology · 2019Review
- The Foodborne StrainMicroorganisms · 2019Article
- A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans.Scientific reports · 2018Article
- Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging.PLoS genetics · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) forms as a consequence of oxidative stress, and acts as a signaling molecule or, at superphysiological levels, as a toxicant. The steady-state concentration of the compound reflects the balance between its generation and its metabolism, primarily through glutathione conjugation. Using an RNAi-based screen, we identified in Caenorhabditis elegans five glutathione transferases (GSTs) capable of catalyzing 4-HNE conjugation. RNAi knock-down of these GSTs (products of the gst-5, gst-6, gst-8, gst-10, and gst-24 genes) sensitized the nematode to electrophilic stress elicited by exposure to 4-HNE. However, interference with the expression of only two of these genes (gst-5 and gst-10) significantly shortened the life span of the organism. RNAi knock-down of the other GSTs resulted in at least as much 4-HNE adducts, suggesting tissue specificity of effects on longevity. Our results are consistent with the oxidative stress theory of organismal aging, broadened by considering electrophilic stress as a contributing factor. According to this extended hypothesis, peroxidation of lipids leads to the formation of 4-HNE in a chain reaction which amplifies the original damage. 4-HNE then acts as an "aging effector" via the formation of 4-HNE-protein adducts, and a resulting change in protein function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.