Evidence map›Paper›PMID 17156495›Full record

ArticleEpidemiology and infection2007

Distribution of novel and previously investigated virulence genes in colonizing and invasive isolates of Streptococcus agalactiae.

T C Smith, S A Roehl, P Pillai, S Li, C F Marrs, B Foxman

Open access · greenAbstract read
In one paragraph

Article in Epidemiology and infection, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  8. Multidrug Resistance and Molecular Characterization ofFrontiers in cellular and infection microbiology · 2021
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  10. Antibiotic Resistance and Molecular Epidemiological Characteristics ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020
    Article
  11. A Vaccine Against Group BInfection and drug resistance · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Comparative genomics of oral isolates of Streptococcus mutans by in silico genome subtraction does not reveal accessory DNA associated with severe early childhood caries.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014
    Article
  16. Genotypes and virulence genes in group B streptococcus isolated in the maternity hospital, Kuwait.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013
    Article
  17. Article
  18. Article
  19. Article
  20. Epidemiology of and prenatal molecular distinction between invasive and colonizing group B streptococci in The Netherlands and Taiwan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

T C SmithDepartment of Epidemiology, University of Iowa, Iowa City, IA 52242, USA. tara-smith@uiowa.edu
S A Roehl
P Pillai
S Li
C F Marrs
B Foxman
University of Michigan–Ann Arbor · USUniversity of Iowa · US

Funding

GBS: Epidemiologic Characterization for Gene DiscoveryR01AI051675 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOXMAN, BETSY · 2003 to 2007
$2.3M
NIAID NIH HHS R01 AI051675NIAID NIH HHS R01AI051675
6 · The paper itself

Abstract

Although Streptococcus agalactiae has emerged as an important cause of invasive disease, relatively little is known regarding the genetic basis of virulence of this organism. Three novel genes with characteristics suggesting a role in virulence were identified via comparison of sequenced genomes of S. agalactiae. The presence of these genes and of the previously identified genes bac, bca, rib, and spb1 was determined, and isolates were assigned a binary genetic signature. It was found that isolates containing spb1, previously suggested to be limited to serotype III-3, were represented by 18 different genetic signatures and several serotypes, and that the presence of both sbp1 and rib was more predictive of invasive disease than spb1 alone. Additionally, bac-positive isolates, reported to be genetically homogeneous, were represented by 14 different genetic signatures. Finally, the majority of serotype V isolates examined contained zero or only one of the genes tested, suggesting that much remains undiscovered regarding important virulence factors in isolates of this serotype.

Indexed as

Genes, BacterialAgedBacterial ProteinsFemaleHumansInfantInfant, NewbornMaleMembrane ProteinsSerotypingStreptococcus agalactiaeVirulence FactorsBacterial ProteinsMembrane ProteinsSpb1 protein, Streptococcus agalactiaeVirulence Factors

Identifiers

PMID17156495
PMCPMC2870641
OpenAlexW2151969839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.