ArticleGenome biology2006
Dynamic usage of transcription start sites within core promoters.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 90 citations in OpenAlex.
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- A two-stream convolutional neural network for microRNA transcription start site feature integration and identification.Scientific reports · 2021Article
- Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae.Genome biology · 2020Article
- CRISPRa-mediatedCell & bioscience · 2019Article
- RNA-sequence analysis of gene expression from honeybees (Apis mellifera) infected with Nosema ceranae.PloS one · 2017Article
- Genome-wide uniformity of human 'open' pre-initiation complexes.Genome research · 2017Article
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- Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila.PLoS genetics · 2016Article
- Construction of a Transcription Map for Papillomaviruses using RACE, RNase Protection, and Primer Extension Assays.Current protocols in microbiology · 2016Article
- Genome-wide identification and characterization of transcription start sites and promoters in the tunicate Ciona intestinalis.Genome research · 2016Article
- Core Promoter Plasticity Between Maize Tissues and Genotypes Contrasts with Predominance of Sharp Transcription Initiation Sites.The Plant cell · 2015Article
- Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammalian promoters do not initiate transcription at single, well defined base pairs, but rather at multiple, alternative start sites spread across a region. We previously characterized the static structures of transcription start site usage within promoters at the base pair level, based on large-scale sequencing of transcript 5' ends.
resultsIn the present study we begin to explore the internal dynamics of mammalian promoters, and demonstrate that start site selection within many mouse core promoters varies among tissues. We also show that this dynamic usage of start sites is associated with CpG islands, broad and multimodal promoter structures, and imprinting.
conclusionOur results reveal a new level of biologic complexity within promoters--fine-scale regulation of transcription starting events at the base pair level. These events are likely to be related to epigenetic transcriptional regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.