ArticleBMC developmental biology2006
Implantation Serine Proteinases heterodimerize and are critical in hatching and implantation.
Article in BMC developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- PRSS38 Is a Novel Sperm Serine Protease Involved in Human and Mouse Fertilization.International journal of molecular sciences · 2025Article
- Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling.Reproduction (Cambridge, England) · 2022Review
- Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular evolution of hatching enzymes and their paralogous genes in vertebrates.BMC ecology and evolution · 2022Article
- Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk.International journal of molecular sciences · 2019Review
- Article
- The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.Human molecular genetics · 2017Article
- Effect of L-carnitine on in vitro developmental rate, the zona pellucida and hatching of blastocysts and their cell numbers in mouse embryos.International journal of reproductive biomedicine · 2016Article
- Differential regulation of receptivity in two uterine horns of a recipient mouse following asynchronous embryo transfer.Scientific reports · 2015Article
- Uterine selection of human embryos at implantation.Scientific reports · 2014Article
- Article
- Regulation of proteinases during mouse peri-implantation development: urokinase-type plasminogen activator expression and cross talk with matrix metalloproteinase 9.Reproduction (Cambridge, England) · 2011Article
- Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors.PloS one · 2011Article
- The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation.PloS one · 2010Article
- Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals.BMC genomics · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have recently reported the expression of murine Implantation Serine Proteinase genes in pre-implantation embryos (ISP1) and uterus (ISP1 and ISP2). These proteinases belong to the S1 proteinase family and are similar to mast cell tryptases, which function as multimers.
resultsHere, we report the purification and initial characterization of ISP1 and 2 with respect to their physico-chemical properties and physiological function. In addition to being co-expressed in uterus, we show that ISP1 and ISP2 are also co-expressed in the pre-implantation embryo. Together, they form a heterodimer with an approximate molecular weight of 63 kD. This complex is the active form of the enzyme, which we have further characterized as being trypsin-like, based on substrate and inhibitor specificities. In addition to having a role in embryo hatching and outgrowth, we demonstrate that ISP enzyme is localized to the site of embryo invasion during implantation and that its activity is important for successful implantation in vivo.
conclusionOn the basis of similarities in structural, chemical, and functional properties, we suggest that this ISP enzyme complex represents the classical hatching enzyme, strypsin. Our results demonstrate a critical role for ISP in embryo hatching and implantation.
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