Evidence map›Paper›PMID 17154650›Full record

ReviewMolecular diagnosis & therapy2006

Biomarkers for the development of cancer vaccines: current status.

John Copier, Mike Whelan, Angus Dalgleish

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diagnosis & therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John CopierDepartment of Oncology, Division of Cellular and Molecular Medicine, St George's University of London, London, UK.
Mike Whelan
Angus Dalgleish

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant improvements in our knowledge of tumor immunology have resulted in more sophisticated vaccine approaches for the treatment of cancer. However, research into biomarkers that correlate with the clinical outcome of immunotherapy has lagged behind vaccine development. To this extent, very few immunological or other markers exist that can be used in clinical trials for immunotherapy. In this review, we discuss the current status of biomarker development specifically for the monitoring and development of cancer vaccines. This includes immunological biomarkers (measurement of T-cell and cytokine responses), autoimmunity as a correlate for treatment outcome, and the possible development of multiple biomarkers using high-throughput proteomics technologies. The generation of such biomarkers will allow us to make clinical decisions about patient treatment at an earlier stage and should aid in shortening the development time for vaccines.

Indexed as

AnimalsAntigen-Presenting CellsAntigens, NeoplasmBiomarkers, TumorCancer VaccinesDendritic CellsFemaleHumansImmunotherapy, ActiveMaleMelanomaNeoplasmsOligonucleotide Array Sequence AnalysisOvarian NeoplasmsPredictive Value of TestsProstatic NeoplasmsAntigens, NeoplasmBiomarkers, TumorCancer VaccinesTissue ExtractsVaccines, DNA

Identifiers

PMID17154650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.