ArticleNaunyn-Schmiedeberg's archives of pharmacology2007
Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A prospective randomized controlled trial of omeprazole for preventing esophageal stricture in grade 2b and 3a corrosive esophageal injuries.Surgical endoscopy · 2021Trial
- Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation.Life (Basel, Switzerland) · 2023Article
- Vagus Nerve Stimulation Reduces Indomethacin-Induced Small Bowel Inflammation.Frontiers in neuroscience · 2021Article
- Histamine HInternational journal of molecular sciences · 2020Article
- Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.Brain, behavior, and immunity · 2019Article
- Risk Factors for Esophageal Stricture in Grade 2b and 3a Corrosive Esophageal Injuries.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum.Toxicology · 2017Article
- The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model.Gut and liver · 2016Article
- Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling.Biochemical pharmacology · 2015Article
- Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.Digestive diseases and sciences · 2014Article
- The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The impact of non-steroidal anti-inflammatory drugs on the small intestinal epithelium.Journal of clinical biochemistry and nutrition · 2014Review
- Proanthocyanidin from grape seed extracts protects indomethacin-induced small intestinal mucosal injury.Gastroenterology research and practice · 2014Article
- Article
- Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.Free radical biology & medicine · 2011Article
- Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes.The Journal of pharmacology and experimental therapeutics · 2011Article
- Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers.Inflammation · 2010Review
- Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole.Journal of clinical biochemistry and nutrition · 2009Article
- Present status and strategy of NSAIDs-induced small bowel injury.Journal of gastroenterology · 2009Review
- Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.Scandinavian journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton pump inhibitors (PPIs) have been shown to be effective in preventing gastric and duodenal ulcers in high-risk patients taking nonsteroidal anti-inflammatory drugs (NSAIDs); by contrast, scarce information is available concerning the effects of PPIs on intestinal damage induced by NSAIDs in humans or in experimental animals. We examined the effects of lansoprazole and omeprazole on the intestinal injury induced by indomethacin in the conscious rat. PPIs were administered by the intragastric route at 30, 60 and 90 micromol/kg, 12 h and 30 min before and 6 h after indomethacin treatment. The effects of omeprazole and lansoprazole were evaluated on: (1) macroscopic and histologic damage; (2) mucosal polymorphonuclear cell infiltration; (3) oxidative tissue damage and (4) bacterial translocation from lumen into the intestinal mucosa. Lansoprazole and omeprazole (at 90 micromol/kg) significantly decreased (P<0.01) the macroscopic and histologic damage induced by indomethacin in the rat small intestine. Furthermore, both drugs greatly reduced (P<0.01) the associated increases in myeloperoxidase levels and lipid peroxidation induced by indomethacin, whereas they only moderately affected (P<0.05) the translocation of enterobacteria from lumen into the intestinal mucosa. These data demonstrate that omeprazole and lansoprazole can protect the small intestine from the damage induced by indomethacin in the conscious rat. The intestinal protection, possibly related to antioxidant and anti-inflammatory properties of these drugs, may suggest new therapeutic uses of PPIs in intestinal inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.