ArticleDigestive diseases and sciences2007
Antioxidant effects of metronidazole in colonic tissue.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers.European journal of clinical pharmacology · 2010Trial
- Article
- Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease.Frontiers in physiology · 2021Review
- Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research.Oxidative medicine and cellular longevity · 2018Article
- Colonic Fermentation Promotes Decompression sickness in Rats.Scientific reports · 2016Article
- A filtered database search algorithm for endogenous serum protein carbonyl modifications in a mouse model of inflammation.Molecular & cellular proteomics : MCP · 2011Article
- Differential effects of Bifidobacterium pseudolongum strain Patronus and metronidazole in the rat gut.Applied and environmental microbiology · 2009Article
- Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.Journal of parasitology research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species, primarily generated in the mitochondria, contribute to tissue injury in inflammatory bowel diseases. The efficacy of metronidazole (MTZ) in some situations of inflammatory bowel disease may result not only from its antibiotic effect, but also from an antioxidant effect. We evaluated, under physiologic conditions, the antioxidant potential of MTZ on the biomarkers of oxidative damage to proteins (protein carbonyls), lipids (malondialdehyde), and the levels of antioxidant defense (glutathione) in the small bowel, large bowel, and liver of control and MTZ-treated rats. Basal levels of protein carbonyls and malondialdehyde were significantly higher in the colon compared with those in the small intestine, whereas glutathione levels were quite similar along the bowel. MTZ reduced significantly the colonic oxidative damage to proteins without any side effect in the liver. This is the first evidence of an antioxidant effect of MTZ on oxidative protein damage in the colon under physiologic conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.