ArticleBiology of reproduction2007
Effect of the conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization.
Article in Biology of reproduction, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.International journal of molecular sciences · 2020Article
- Immune responses at the maternal-fetal interface.Science immunology · 2019Review
- Mapping of estradiol binding sites through receptor micro-autoradiography in the endometrial stroma of early pregnant mice.Histochemistry and cell biology · 2017Article
- Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model.JCI insight · 2016Article
- Leukocyte driven-decidual angiogenesis in early pregnancy.Cellular & molecular immunology · 2014Review
- Role of decidual natural killer cells, interleukin-15, and interferon-γ in placental development and preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids.Cell and tissue research · 2012Article
- Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis.Reproduction (Cambridge, England) · 2012Article
- Endometrial decidualization does not trigger the blood pressure decline of normal early pregnancy in mice.Biology of reproduction · 2012Article
- Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization.Reproduction (Cambridge, England) · 2011Article
- Tumor necrosis factor receptor subfamily 9 (Tnfrsf9) gene is expressed in distinct cell populations in mouse uterus and conceptus during implantation period of pregnancy.Cell and tissue research · 2011Article
- Microarray assessment of the influence of the conceptus on gene expression in the mouse uterus during decidualization.Reproduction (Cambridge, England) · 2011Article
- Do molecular signals from the conceptus influence endometrium decidualization in rodents?Journal of experimental zoology. Part B, Molecular and developmental evolution · 2009Review
- Paracrine signals from the mouse conceptus are not required for the normal progression of decidualization.Endocrinology · 2009Article
- Murine endometrial and decidual NK1.1+ natural killer cells display a B220+CD11c+ cell surface phenotype.Biology of reproduction · 2009Article
- Interferon gamma in successful pregnancies.Biology of reproduction · 2009Review
- UNK cells: their role in tissue re-modelling and preeclampsia.Seminars in immunopathology · 2007Review
- The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells.Reproduction (Cambridge, England) · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Uterine natural killer (uNK) cells are the most abundant lymphocytes in the uterus during early pregnancy and play a role in spiral arteriole modifications. In the present study, we investigated whether uNK cell populations differed between mouse decidua and deciduoma. Histochemical staining using the Dolichos biflorus agglutinin (DBA) lectin was used to identify uNK cells and classify their stages of maturation. We found differences in the pattern of localization and density of uNK cells between the decidua and deciduoma at Days 2-4 after the onset of decidualization. The cells were more distributed and the densities were significantly greater in the mesometrial region of the decidua than in the deciduoma. Using double-labeling for DBA lectin binding and bromodeoxyuridine incorporation, we found that the higher number of uNK cells in the decidua was not due to an increase in uNK cell proliferation. Western blot analyses revealed that the increase in uNK cell number was accompanied by significant increases in the levels of interferon gamma (IFNG) and prointerleukin 18 when a conceptus was present. Vascular morphometry revealed that modifications of the spiral arterioles occurred in the mesometrial decidua but not in the deciduoma, which could be attributed to the differences observed in uNK cell number and IFNG production. The present study demonstrates that differences exist in uNK cell populations between the decidua and deciduoma, providing evidence that the conceptus generates signals that regulate uNK cell number and function in the uterus during implantation.
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