ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Regulation of behavioral and synaptic plasticity by serotonin release within local modulatory fields in the CNS of Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia.PloS one · 2014Article
- Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory.Neurobiology of learning and memory · 2013Review
- Single-neuron transcriptome and methylome sequencing for epigenomic analysis of aging.Methods in molecular biology (Clifton, N.J.) · 2013Article
- A cellular model of memory reconsolidation involves reactivation-induced destabilization and restabilization at the sensorimotor synapse in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.Frontiers in physiology · 2012Article
- Article
- The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Spatial-specific action of serotonin within the leech midbody ganglion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2008Article
- Article
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3 authors.
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Abstract
In Aplysia, serotonergic neurons are widely activated during sensitization training, but the effects of exogenous serotonin (5-HT) on reflex circuits vary, inducing short- or long-term synaptic facilitation or synaptic inhibition, depending on the site of application. During learning, it is possible that specific spatial patterns of 5-HT release evoked by training may produce different phases of sensitization or behavioral inhibition. To test this hypothesis, we examined the modulation of the tail-induced siphon withdrawal reflex by repeated noxious stimuli applied to one of three sites: the (1) ipsilateral or (2) contralateral sides of the tail or (3) the head. Ipsilateral tail shock produced long-term sensitization, whereas contralateral tail shock induced only short-term sensitization, and head shock produced inhibition. In parallel cellular experiments, tail-nerve shock evoked large 5-HT release localized around the ipsilateral tail sensory neurons (SNs) and motor neurons (MNs) but only modest 5-HT release in the contralateral pleural-pedal ganglia and in the abdominal ganglion, in which the siphon MNs are located. Head-nerve shock, in contrast, produced only modest 5-HT release in the pleural, pedal, and abdominal ganglia. Thus, each training protocol evoked a specific pattern of 5-HT release within the CNS. In addition, we found that 5-HT released in the pleural ganglia was correlated with facilitation of SN-MN synapses; however, in the abdominal ganglion, it was associated with inhibition of the synapses between identified interneurons (L29s) and siphon MNs (LFSs). Because 5-HT differentially modulates synaptic efficacy at different synaptic sites, our data can explain how specific spatial patterns of 5-HT release in local modulatory fields can contribute to the induction of short- or long-term sensitization or to behavioral inhibition.
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