ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Tumor necrosis factor potentiates central vagal afferent signaling by modulating ryanodine channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of overshadowing on conditioned and unconditioned nausea in a rotation paradigm with humans.Experimental brain research · 2014Trial
- Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.Current neurology and neuroscience reports · 2026Review
- Colitis-associated gut-vagus-brain signaling integrates tumorigenesis and neuroinflammation: comparative regulation by vagotomy and atropine.Journal of neuroinflammation · 2026Article
- Neural representation of cytokines by vagal sensory neurons.Nature communications · 2025Article
- Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.International journal of molecular sciences · 2021Review
- Neuroimmune Communication in Health and Disease.Physiological reviews · 2018Review
- Response of catecholaminergic neurons in the mouse hindbrain to glucoprivic stimuli is astrocyte dependent.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation.Gastroenterology · 2017Review
- TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Calcium-overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa.Acute medicine & surgery · 2015Article
- Divergent neuroendocrine responses to localized and systemic inflammation.Seminars in immunology · 2014Review
- Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction.Ageing research reviews · 2013Review
- Capsaicin-sensitive vagal afferent neurons contribute to the detection of pathogenic bacterial colonization in the gut.Journal of neuroimmunology · 2013Article
- Astrocytes in the hindbrain detect glucoprivation and regulate gastric motility.Autonomic neuroscience : basic & clinical · 2013Review
- Astrocytes in the nucleus of the solitary tract are activated by low glucose or glucoprivation: evidence for glial involvement in glucose homeostasis.Frontiers in neuroscience · 2013Article
- The unsilent majority-TRPV1 drives "spontaneous" transmission of unmyelinated primary afferents within cardiorespiratory NTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract.Journal of neurophysiology · 2011Article
- Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signaling.Brain research · 2009Article
- Proteinase-activated receptors in the nucleus of the solitary tract: evidence for glial-neural interactions in autonomic control of the stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Disease processes such as infection, leukemia, and autoimmune disorders are often associated with nausea, emesis, and anorexia. A common denominator of these rather disparate states is the production of the early, proinflammatory cytokine tumor necrosis factor-alpha (TNF) in significant quantities. Recent studies have shown that TNF may act as a neuromodulator in the hindbrain to produce malaise by potentiating visceral afferent signaling at the central processes of the vagus nerve. However, the mechanism by which TNF produces this signal amplification is not known. Our time-lapse calcium imaging studies of individual central vagal afferent varicosities in the caudal brainstem slice preparation show that, although TNF has minimal direct effects to elevate terminal intracellular calcium levels, TNF does potentiate the terminal afferent responses to other stimuli through a ryanodine-based, calcium-induced calcium release mechanism. Such a scheme may explain how TNF sensitizes visceral as well as somatosensory primary afferents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.