ArticleGenetics2007
Exploratory activity in Drosophila requires the kurtz nonvisual arrestin.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Short-term cold acclimation influences Rhyzopertha dominica (Coleoptera: Bostrichidae) mobility in different temperatures.Journal of insect science (Online) · 2026Article
- opynfield: An Open-Source Python Package for the Analysis of Open Field Exploration Data.Neuroinformatics · 2025Article
- Neurofibromin Deficiency Alters the Patterning and Prioritization of Motor Behaviors in a State-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Capturing continuous, long timescale behavioral changes in Drosophila melanogaster postural data.PLoS computational biology · 2025Article
- Energy Reserve Allocation in the Trade-Off between Migration and Reproduction in Fall Armyworm.Insects · 2024Article
- Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner.bioRxiv : the preprint server for biology · 2024Article
- Article
- Mutants of theInternational journal of molecular sciences · 2021Article
- Article
- The Panopticon-Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference.Frontiers in behavioral neuroscience · 2021Article
- Aging mechanisms-A perspective mostly fromAdvanced genetics (Hoboken, N.J.) · 2020Article
- Article
- Sex differences in dispersal syndrome are modulated by environment and evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Wall following in Xenopus laevis is barrier-driven.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Shape and size of the arenas affect amphipod behaviours: implications for ecotoxicology.PeerJ · 2018Article
- The white gene controls copulation success in Drosophila melanogaster.Scientific reports · 2017Article
- Article
- White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila.PloS one · 2017Article
- Article
- Neurofibromin Loss of Function Drives Excessive Grooming in Drosophila.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
When Drosophila adults are placed into an open field arena, they initially exhibit an elevated level of activity followed by a reduced stable level of spontaneous activity. We have found that the initial elevated component arises from the fly's interaction with the novel arena since: (1) the increased activity is independent of handling prior to placement within the arena, (2) the fly's elevated activity is proportional to the size of the arena, and (3) the decay in activity to spontaneous levels requires both visual and olfactory input. These data indicate that active exploration is the major component of elevated initial activity. There is a specific requirement for the kurtz nonvisual arrestin in the nervous system for both the exploration stimulated by the novel arena and the mechanically stimulated activity. kurtz is not required for spontaneous activity; kurtz mutants display normal levels of spontaneous activity and average the same velocities as wild-type controls. Inhibition of dopamine signaling has no effect on the elevated initial activity phase in either wild-type or krz(1) mutants. Therefore, the exploratory phase of open field activity requires kurtz in the nervous system, but is independent of dopamine's stimulation of activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.