ArticleProceedings of the National Academy of Sciences of the United States of America2006
Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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Who cites it
53 citing papers in PubMed, 85 citations in OpenAlex.
- Multi-omics characterization of radiation-induced cerebellar remodeling and tumorigenic transcriptional programs.Neoplasia (New York, N.Y.) · 2026Article
- Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity.Epigenomics · 2026Article
- Article
- Evidence That Dmrta2 Acts through Repression ofeNeuro · 2025Article
- Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and function.Cell reports · 2025Article
- Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction.Frontiers in cellular neuroscience · 2025Review
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes.Genes & development · 2021Article
- Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis.Frontiers in cell and developmental biology · 2021Review
- ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus.Development (Cambridge, England) · 2020Article
- Strain-Dependent Modifier Genes Determine Survival inG3 (Bethesda, Md.) · 2020Article
- BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs.Cell death & disease · 2020Article
- ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities.PLoS genetics · 2020Article
- The ClassicGenetics · 2020Article
- DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor.Precision clinical medicine · 2019Article
- Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation.Molecular and cellular biology · 2019Article
- The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.PloS one · 2019Article
- Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.Molecular and cellular biology · 2018Article
- Moving into shape: cell migration during the development and histogenesis of the cerebellum.Histochemistry and cell biology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Neural stem cells and progenitors in the developing brain must choose between proliferation with renewal and differentiation. Defects in navigating this choice can result in malformations or cancers, but the genetic mechanisms that shape this choice are not fully understood. We show by positional cloning that the 30-zinc finger transcription factor Zfp423 (OAZ) is required for patterning the development of neuronal and glial precursors in the developing brain, particularly in midline structures. Mutation of Zfp423 results in loss of the corpus callosum, reduction of hippocampus, and a malformation of the cerebellum reminiscent of human Dandy-Walker patients. Within the cerebellum, Zfp423 is expressed in both ventricular and external germinal zones. Loss of Zfp423 results in diminished proliferation by granule cell precursors in the external germinal layer, especially near the midline, and abnormal differentiation and migration of ventricular zone-derived neurons and Bergmann glia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.