ArticleDevelopmental biology2007
C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
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- Genetic architecture for skeletal muscle glycolytic potential in Chinese Erhualian pigs revealed by a genome-wide association study using 1.4M SNP array.Frontiers in genetics · 2023Article
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- GWAS for Meat and Carcass Traits Using Imputed Sequence Level Genotypes in Pooled F2-Designs in Pigs.G3 (Bethesda, Md.) · 2019Article
- The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway.Cell death and differentiation · 2019Article
- Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration.Frontiers in immunology · 2018Article
- Response of turkey muscle satellite cells to thermal challenge. I. transcriptome effects in proliferating cells.BMC genomics · 2017Article
- Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.Omics : a journal of integrative biology · 2017Article
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- Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity.BMC genomics · 2016Article
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- Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.Journal of cell science · 2015Article
- FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis.Developmental biology · 2013Article
- Myoblast fusion: lessons from flies and mice.Development (Cambridge, England) · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have identified a gene by microarray analysis that is located on chromosome 6 (c6orf32), whose expression is increased during human fetal myoblast differentiation. The protein encoded by c6orf32 is expressed both in myogenic and non-myogenic primary cells isolated from 18-week old human fetal skeletal muscle. Immunofluorescent staining indicated that C6ORF32 localizes to the cellular cytoskeleton and filopodia, and often displays polarized expression within the cell. mRNA knockdown experiments in the C2C12 murine myoblast cell line demonstrated that cells lacking c6orf32 exhibit a myogenic differentiation defect, characterized by a decrease in the expression of myogenin and myosin heavy chain (MHC) proteins, whereas MyoD1 was unaltered. In contrast, overexpression of c6orf32 in C2C12 or HEK293 cells (a non-muscle cell line) promoted formation of long membrane protrusions (filopodia). Analysis of serial deletion mutants demonstrated that amino acids 55-113 of C6ORF32 are likely involved in filopodia formation. These results indicate that C6ORF32 is a novel protein likely to play multiple functions, including promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.