ArticleThe Journal of membrane biology1991
Inner mitochondrial membrane anion channel is present in brown adipocytes but is not identical with the uncoupling protein.
Article in The Journal of membrane biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Patch-clamp technique to study mitochondrial membrane biophysics.The Journal of general physiology · 2023Article
- Patch-Clamp Analysis of the Mitochondrial HFrontiers in physiology · 2020Article
- Electro-pharmacological profiles of two brain mitoplast anion channels: Inferences from single channel recording.EXCLI journal · 2017Article
- Anion Channels of Mitochondria.Handbook of experimental pharmacology · 2017Review
- Mitochondrial chloride channels: electrophysiological characterization and pH induction of channel pore dilation.European biophysics journal : EBJ · 2013Article
- Modulation of the hepatocyte rough endoplasmic reticulum single chloride channel by nucleotide-Mg2+ interaction.Pflugers Archiv : European journal of physiology · 2012Article
- Mitochondrial ion channels as therapeutic targets.FEBS letters · 2010Review
- Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate--DIDS.Journal of bioenergetics and biomembranes · 2007Article
- Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels.Cellular & molecular biology letters · 2007Article
- Anion channels of the inner membrane of mammalian and yeast mitochondria.Journal of bioenergetics and biomembranes · 1996Review
- Electrophysiology of the inner mitochondrial membrane.Journal of bioenergetics and biomembranes · 1994Review
- Single anion channels reconstituted from cardiac mitoplasts.The Journal of membrane biology · 1993Article
- Modulation of inner mitochondrial membrane channel activity.Journal of bioenergetics and biomembranes · 1992Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vesicles of inner mitochondrial membrane, mitoplasts, from rat brown adipose tissue were prepared by osmotic swelling and studied using the patch-clamp technique. Current events of a 107.8 +/- 8.7 pS (n = 16, 21 degrees C) channel were recorded in the mitoplast-attached mode. This channel was selective for anions and its kinetics resembled those of channels previously found in liver and heart mitochondria of mouse and ox. In whole-mitoplast mode each of five purine nucleotides (20 microM) blocked the channel. This is the first demonstration of pharmacological blockade of this type of channel. Although a similar anion channel in mouse and ox mitochondria was suggested to be the uncoupling protein (UCP) associated with nonshivering thermogenesis, we present several arguments against this possibility. Thus we describe a high-conductance, purine-nucleotide-binding, anion selective mitochondrial channel, that is not the UCP.
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