Evidence map›Paper›PMID 17149589›Full record

Trial reportDiabetologia2007

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism.

F Shojaee-Moradie, K C R Baynes, C Pentecost, J D Bell, E L Thomas, N C Jackson, M Stolinski, M Whyte, D Lovell, S B Bowes and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894527 (Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome), which is not on this map. Cited by 77 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03894527 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome

TypeinterventionalSponsorUniversity of VirginiaRan2019 to 2020Enrolled16ConditionsMetabolic Syndrome, ObesityArmsSingle Bout of Exercise, Control Condition
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 211 citations in OpenAlex.

  1. Relationship between aerobic fitness and adipose tissue insulin resistance.American journal of physiology. Endocrinology and metabolism · 2026
    Pooled it
  2. Pooled it
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  6. Guideline
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  8. Influence of Prenatal Aerobic Exercise on Fetal Morphometry.Maternal and child health journal · 2020
    Trial
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  15. Review
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  20. Exercise as a tool to mitigate metabolic disease.American journal of physiology. Cell physiology · 2024
    Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

F Shojaee-MoradieDepartment of Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine, King's College London, London, UK. f.shojaee-moradie@surrey.ac.uk
K C R Baynes
C Pentecost
J D Bell
E L Thomas
N C Jackson
M Stolinski
M Whyte
D Lovell
S B Bowes
J Gibney
R H Jones
A M Umpleby
King's College London · GBHammersmith Hospital · GBUniversity of Surrey · GB

Funding

Medical Research Council MC_U120061305
6 · The paper itself

Abstract

aims/hypothesisIt is not known whether the beneficial effects of exercise training on insulin sensitivity are due to changes in hepatic and peripheral insulin sensitivity or whether the changes in insulin sensitivity can be explained by adaptive changes in fatty acid metabolism, changes in visceral fat or changes in liver and muscle triacylglycerol content. We investigated the effects of 6 weeks of supervised exercise in sedentary men on these variables. SUBJECTS AND

methodsWe randomised 17 sedentary overweight male subjects (age 50 +/- 2.6 years, BMI 27.6 +/- 0.5 kg/m(2)) to a 6-week exercise programme (n = 10) or control group (n = 7). The insulin sensitivity of palmitic acid production rate (Ra), glycerol Ra, endogenous glucose Ra (EGP), glucose uptake and glucose metabolic clearance rate were measured at 0 and 6 weeks with a two-step hyperinsulinaemic-euglycaemic clamp [step 1, 0.3 (low dose); step 2, 1.5 (high dose) mU kg(-1) min(-1)]. In the exercise group subjects were studied >72 h after the last training session. Liver and skeletal muscle triacylglycerol content was measured by magnetic resonance spectroscopy and visceral adipose tissue by cross-sectional computer tomography scanning.

resultsAfter 6 weeks, fasting glycerol, palmitic acid Ra (p = 0.003, p = 0.042) and NEFA concentration (p = 0.005) were decreased in the exercise group with no change in the control group. The effects of low-dose insulin on EGP and of high-dose insulin on glucose uptake and metabolic clearance rate were enhanced in the exercise group but not in the control group (p = 0.026; p = 0.007 and p = 0.04). There was no change in muscle triacylglycerol and liver fat in either group. CONCLUSIONS/

interpretationDecreased availability of circulating NEFA may contribute to the observed improvement in the insulin sensitivity of EGP and glucose uptake following 6 weeks of moderate exercise.

Indexed as

ExerciseOverweightBlood GlucoseBody Mass IndexFatty AcidsFatty Acids, NonesterifiedGlucose Clamp TechniqueHumansInsulinLife StyleMaleMiddle AgedPalmitic AcidBlood GlucoseFatty AcidsFatty Acids, NonesterifiedInsulinPalmitic Acid

Identifiers

PMID17149589
OpenAlexW1975525226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.