ArticleDevelopmental neuroscience2007
Citron kinase is required for postnatal neurogenesis in the hippocampus.
Article in Developmental neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Article
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- Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.Epigenetics · 2024Article
- Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane.Molecular biology of the cell · 2024Article
- Of rings and spines: The multiple facets of Citron proteins in neural development.Small GTPases · 2020Review
- Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.eLife · 2018Article
- Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.Cell reports · 2017Article
- CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.Human genetics · 2016Article
- ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.EMBO reports · 2016Article
- Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.American journal of human genetics · 2016Article
- Molecular approaches for manipulating astrocytic signaling in vivo.Frontiers in cellular neuroscience · 2015Review
- Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.Nature genetics · 2014Article
- Rho GTPases in animal cell cytokinesis: an occupation by the one percent.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: effects on cell cycle kinetics.The Journal of comparative neurology · 2011Article
- Review
- Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.BMC systems biology · 2008Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
The dentate gyrus is a site of continual neurogenesis in the postnatal mammalian brain. Here we investigated postnatal neurogenesis in the citron kinase (citron-K) null-mutant rat (flathead). The flathead rat has substantial deficits in embryonic neurogenesis that are due to failed cytokinesis and cell death. We report here the loss of citron-K function has an even severer effect on postnatal neurogenesis in the dentate gyrus. Analysis of phosphorylated histone H3 expression in postnatal neurogenic regions of the flathead mutant revealed a complete lack of mitotic cells in the dentate gyrus and a large reduction in the number of dividing cells in the flathead subventricular zone. Examination of 5-bromodeoxyuridine incorporation in the flathead rat revealed that the flathead rat had a 99% reduction in the number of newly generated cells in the dentate gyrus at postnatal day 10. In addition, doublecortin-positive cells were essentially absent from the postnatal flathead dentate gyrus which also lacked the vimentin- and nestin-positive radial glia scaffold that defines the neurogenic niche in the postnatal subgranular zone. Together these results indicate that postnatal neurogenesis in the dentate gyrus is eliminated by loss of citron-K function, and suggests that a citron-K-dependent progenitor lineage forms the postnatal neuronal progenitor population in the dentate gyrus.
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