ArticleThe American journal of pathology2006
Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- The P2YCellular and molecular life sciences : CMLS · 2022Article
- SOCS proteins and their roles in the development of glioblastoma.Oncology letters · 2022Review
- Prognostic values of signal transducers activators of transcription in gastric cancer.Bioscience reports · 2019Article
- kshv-mir-k12-1-5p promotes cell growth and metastasis by targeting SOCS6 in Kaposi's sarcoma cells.Cancer management and research · 2019Article
- miR-885-5p upregulation promotes colorectal cancer cell proliferation and migration by targeting suppressor of cytokine signaling.Oncology letters · 2018Article
- Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- 15-Deoxy-Δ(12,14)-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells.PPAR research · 2016Article
- Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis.Medical oncology (Northwood, London, England) · 2015Article
- Akacid medical formulation induces apoptosis in myeloid and lymphatic leukemic cell lines in vitro and in vivo.PloS one · 2015Article
- SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.Endocrine-related cancer · 2014Article
- The role of suppressors of cytokine signalling in human neoplasms.Molecular biology international · 2014Review
- Proinflammatory cytokine interleukin-6 in prostate carcinogenesis.American journal of clinical and experimental urology · 2014Review
- Lymph node metastasis is mediated by suppressor of cytokine signaling-3 in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Expression of SOCSs in human prostate cancer and their association in prognosis.Molecular and cellular biochemistry · 2013Article
- Interleukin-6: a multifunctional targetable cytokine in human prostate cancer.Molecular and cellular endocrinology · 2012Review
- Increased renal versican expression is associated with progression of chronic kidney disease.PloS one · 2012Article
- Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction.Diabetes · 2011Article
- Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma.Reproductive biology and endocrinology : RB&E · 2010Article
- IL-17 enhancement of the IL-6 signaling cascade in astrocytes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Interleukin-6, levels of which are elevated in prostate cancer, activates different signal transduction pathways including that of Janus kinases/signal transducer and activator of transcription (STAT)3. However, phosphorylation of STAT3 has been reported to be associated with either stimulatory or inhibitory effects on cellular proliferation. To better understand the mechanisms of STAT3 regulation in benign and malignant prostate, we have investigated the role of suppressor of cytokine signaling (SOCS)-3. Cell lines that did not express phosphorylated STAT3 were found to be SOCS-3-positive. SOCS-3 was re-expressed in LNCaP cells after treatment with a demethylating agent. SOCS-3 immunohistochemistry revealed a negative or weak reaction in benign areas, whereas its expression was detected in tumor tissue. To investigate the involvement of SOCS-3 in regulation of cellular events, we incubated cancer cells with a cAMP derivative. This treatment yielded higher SOCS-3 levels, reduced [3H]thymidine incorporation, and increased percentage of apoptotic cells. However, down-regulation of SOCS-3 by a short interfering RNA approach resulted in inhibition of proliferation and an increased apoptotic rate. Collectively, our results show that SOCS-3 antagonizes regulation of cellular events by cAMP and is expressed in human prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.