ArticleThe American journal of pathology2006
Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB-International journal of molecular sciences · 2024Article
- Diversity of Volatile Compounds in Raw Milk with Different n-6 to n-3 Fatty Acid Ratio.Animals : an open access journal from MDPI · 2022Article
- Plasma Metabolomic Profiles Differentiate Patients With Dilated Cardiomyopathy and Ischemic Cardiomyopathy.Frontiers in cardiovascular medicine · 2020Article
- n-3 PUFA Sources (Precursor/Products): A Review of Current Knowledge on Rabbit.Animals : an open access journal from MDPI · 2019Review
- Alpha linolenic acid decreases apoptosis and oxidized phospholipids in cardiomyocytes during ischemia/reperfusion.Molecular and cellular biochemistry · 2018Article
- Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies.International journal of medical sciences · 2016Article
- Creatine, L-carnitine, and ω3 polyunsaturated fatty acid supplementation from healthy to diseased skeletal muscle.BioMed research international · 2014Article
- Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial.Journal of cardiovascular disease research · 2013Article
- Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.American journal of physiology. Heart and circulatory physiology · 2013Article
- Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes.Molecular biology reports · 2012Article
- Effect of palmitic acid and linoleic acid on expression of ICAM-1 and VCAM-1 in human bone marrow endothelial cells (HBMECs).Archives of medical science : AMS · 2012Article
- Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.Circulation research · 2012Review
- High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.Cardiovascular research · 2012Article
- The role of dietary fatty acids in predicting myocardial structure in fat-fed rats.Lipids in health and disease · 2011Article
- A comparison of the heart and muscle total lipid and fatty acid profiles of nine large shark species from the east coast of South Africa.Fish physiology and biochemistry · 2011Article
- An omega-3 fatty acid-enriched diet prevents skeletal muscle lesions in a hamster model of dystrophy.The American journal of pathology · 2010Article
- Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition.Journal of molecular and cellular cardiology · 2009Article
- omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.Cardiovascular research · 2009Review
- Nutrients: the environmental regulation of cardiovascular gene expression.Genes & nutrition · 2007Article
- Effect of Omega-3 Polyunsaturated Fatty Acid Supplementation in Patients with Atrial Fibrillation.Journal of atrial fibrillationReview
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomized clinical trials have demonstrated that the increased intake of omega-3 polyunsaturated fatty acids significantly reduces the risk of ischemic cardiovascular disease, but no investigations have been performed in hereditary cardiomyopathies with diffusely damaged myocardium. In the present study, delta-sarcoglycan-null cardiomyopathic hamsters were fed from weaning to death with an alpha-linolenic acid (ALA)-enriched versus standard diet. Results demonstrated a great accumulation of ALA and eicosapentaenoic acid and an increased eicosapentaenoic/arachidonic acid ratio in cardiomyopathic hamster hearts, correlating with the preservation of myocardial structure and function. In fact, ALA administration preserved plasmalemma and mitochondrial membrane integrity, thus maintaining proper cell/extracellular matrix contacts and signaling, as well as a normal gene expression profile (myosin heavy chain isoforms, atrial natriuretic peptide, transforming growth factor-beta1) and a limited extension of fibrotic areas within ALA-fed cardiomyopathic hearts. Consequently, hemodynamic indexes were safeguarded, and more than 60% of ALA-fed animals were still alive (mean survival time, 293+/-141.8 days) when all those fed with standard diet were deceased (mean survival time, 175.9+/-56 days). Therefore, the clinically evident beneficial effects of omega-3 polyunsaturated fatty acids are mainly related to preservation of myocardium structure and function and the attenuation of myocardial fibrosis.
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