ArticleProceedings of the National Academy of Sciences of the United States of America2006
The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 102 citations in OpenAlex.
- Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Role of DKxanthenes inJournal of microbiology and biotechnology · 2026Article
- Milestones in the development ofJournal of bacteriology · 2025Review
- An upgradedEngineering microbiology · 2024Article
- Deciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria.ACS central science · 2024Article
- Interactions of DifferentInternational journal of molecular sciences · 2023Article
- Complete Genome Sequence Assembly and Annotation for Myxococcus xanthus Strains DK1050 and DK101.Microbiology resource announcements · 2023Article
- Coenzyme BEnvironmental microbiology · 2022Article
- The potential of facultative predatoryFrontiers in microbiology · 2022Review
- Light-Triggered Carotenogenesis inMicroorganisms · 2021Review
- Copper and Melanin Play a Role inFrontiers in microbiology · 2020Article
- Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility-Imaging Mass Spectrometry and Unsupervised Segmentation.Analytical chemistry · 2019Article
- Mutants defective in the production of encapsulin show a tan-phase-locked phenotype in Myxococcus xanthus.Journal of microbiology (Seoul, Korea) · 2019Article
- Plasticity in oligomerization, operator architecture, and DNA binding in the mode of action of a bacterial BThe Journal of biological chemistry · 2018Article
- Metabolic and Biosynthetic Diversity in Marine Myxobacteria.Marine drugs · 2018Review
- Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome.Nature microbiology · 2018Article
- Review
- Multifaceted Interfaces of Bacterial Competition.Journal of bacteriology · 2016Review
- Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Scientific reports · 2016Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under starvation conditions myxobacteria form multicellular fruiting bodies in which vegetative cells differentiate into heat- and desiccation-resistant myxospores. Myxobacteria in general are a rich source of secondary metabolites that often exhibit biological activities rarely found in nature. Although the involvement of a yellow compound in sporulation and fruiting body formation of Myxococcus xanthus was described almost 30 years ago, the chemical principle of the pigment remained elusive. This work presents the isolation and structure elucidation of a unique class of pigments that were named DKxanthenes (DKX). The corresponding biosynthetic gene cluster was identified, and DKX-negative mutants were constructed to investigate the physiological role of DKX during development. In these mutants, fruiting body formation was delayed. Moreover, severely reduced amounts of viable spores were observed after 120 h of starvation, whereas no viable spores were formed at all after 72 h. The addition of purified DKX to the mutants resulted in the formation of viable spores after 72 h. Even though an antioxidative activity could be assigned to DKX, the true biochemical mechanism underlying the complementation remains to be elucidated.
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