Trial reportThe Journal of clinical endocrinology and metabolism2007
Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca.
Trial report in The Journal of clinical endocrinology and metabolism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling.Journal of medicinal food · 2016Pooled it
- Bone health nutrition issues in aging.Nutrients · 2010Pooled it
- Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial.The American journal of clinical nutrition · 2015Trial
- Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women.Journal of Korean medical science · 2009Trial
- Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology.The Journal of clinical endocrinology and metabolism · 2009Trial
- Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial.The American journal of clinical nutrition · 2009Trial
- Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.The Journal of nutritional biochemistry · 2009Trial
- Isoflavones.Molecules (Basel, Switzerland) · 2019Review
- Review article: health benefits of some physiologically active ingredients and their suitability as yoghurt fortifiers.Journal of food science and technology · 2015Review
- A Bayesian approach to an interlaboratory comparison.Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society · 2015Article
- Plum and soy aglycon extracts superior at increasing bone calcium retention in ovariectomized Sprague Dawley rats.Journal of agricultural and food chemistry · 2014Article
- Ultra-trace analysis ofNuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms · 2013Article
- Calcium isolation from large-volume human urine samples for 41Ca analysis by accelerator mass spectrometry.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2013Article
- Review
- Soy protein diet and exercise training increase relative bone volume and enhance bone microarchitecture in a mouse model of uremia.Journal of bone and mineral metabolism · 2011Article
- Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice.Journal of bone and mineral metabolism · 2011Article
- The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems.Food & function · 2011Review
- Development of 41Ca-based pharmacokinetic model for the study of bone remodelling in humans.Clinical pharmacokinetics · 2011Article
- Interpretation of 41Ca data using compartmental modeling in post-menopausal women.Analytical and bioanalytical chemistry · 2011Article
- Bone-seeking labels as markers for bone turnover: validation of urinary excretion in rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThe purpose of this 3-way crossover study was to identify the effective dose of soy protein isolate enriched with isoflavones for suppressing bone resorption in postmenopausal women using a novel, rapid assessment of antibone resorbing treatments.
methodsThirteen postmenopausal women (>or=6 yr since menopause) were predosed with 41Ca iv. After a 200-d baseline period, subjects were given 43 g soy protein/d that contained 0, 97.5, or 135.5 mg total isoflavones in randomized order. The soy protein isolate powder was incorporated into baked products and beverages. Each 50-d intervention phase was preceded by a 50-d pretreatment phase for comparison. Serum isoflavone levels and biochemical markers were measured at the end of each phase. Twenty-four-hour urine samples were collected approximately every 10 d during each phase for 41Ca/Ca analysis by accelerator mass spectrometry.
resultsSerum isoflavone levels reflected the amount of isoflavones consumed in a dose-dependent manner. None of the isoflavone levels had a significant effect on biochemical markers of bone turnover, urinary cross-linked N teleopeptides of type I collagen and serum osteocalcin, or bone turnover as assessed by urinary 41Ca/Ca ratios.
conclusionsSoy protein with isoflavone doses of up to 135.5 mg/d did not suppress bone resorption in postmenopausal women. This is the first efficacy trial using the novel technique of urinary 41Ca excretion from prelabeled bone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.