ArticleNucleic acids research2007
PROPHECY--a yeast phenome database, update 2006.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- The oxidative cost of losing low temperature viability protein 1 [Ltv1]: insights into cellular damage and homeostasis.FEMS yeast research · 2026Article
- Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine.G3 (Bethesda, Md.) · 2024Article
- Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32.Science advances · 2022Article
- PRECOG: a tool for automated extraction and visualization of fitness components in microbial growth phenomics.BMC bioinformatics · 2016Article
- Genome engineering for improved recombinant protein expression in Escherichia coli.Microbial cell factories · 2014Review
- Article
- Selection of extreme phenotypes: the role of clinical observation in translational research.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Review
- 'Unknown' proteins and 'orphan' enzymes: the missing half of the engineering parts list--and how to find it.The Biochemical journal · 2009Review
- Ontological Discovery Environment: a system for integrating gene-phenotype associations.Genomics · 2009Article
- Yeast translational response to high salinity: global analysis reveals regulation at multiple levels.RNA (New York, N.Y.) · 2008Article
- Acclimation of Saccharomyces cerevisiae to low temperature: a chemostat-based transcriptome analysis.Molecular biology of the cell · 2007Article
- The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex.Molecular biology of the cell · 2007Article
- Identification of genes encoding tRNA modification enzymes by comparative genomics.Methods in enzymology · 2007Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connecting genotype to phenotype is fundamental in biomedical research and in our understanding of disease. Phenomics--the large-scale quantitative phenotypic analysis of genotypes on a genome-wide scale--connects automated data generation with the development of novel tools for phenotype data integration, mining and visualization. Our yeast phenomics database PROPHECY is available at http://prophecy.lundberg.gu.se. Via phenotyping of 984 heterozygous diploids for all essential genes the genotypes analysed and presented in PROPHECY have been extended and now include all genes in the yeast genome. Further, phenotypic data from gene overexpression of 574 membrane spanning proteins has recently been included. To facilitate the interpretation of quantitative phenotypic data we have developed a new phenotype display option, the Comparative Growth Curve Display, where growth curve differences for a large number of mutants compared with the wild type are easily revealed. In addition, PROPHECY now offers a more informative and intuitive first-sight display of its phenotypic data via its new summary page. We have also extended the arsenal of data analysis tools to include dynamic visualization of phenotypes along individual chromosomes. PROPHECY is an initiative to enhance the growing field of phenome bioinformatics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.