ArticleBiology letters2006
Inferring the distribution of mutational effects on fitness in Drosophila.
Article in Biology letters, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- The adaptive state determines the impact of mutations on evolving populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Between but Not Within-Species Variation in the Distribution of Fitness Effects.Molecular biology and evolution · 2023Article
- Inferring the distributions of fitness effects and proportions of strongly deleterious mutations.G3 (Bethesda, Md.) · 2023Article
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size.Genome biology and evolution · 2022Article
- Dominance shifts increase the likelihood of soft selective sweeps.Evolution; international journal of organic evolution · 2022Article
- Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantitative and population genetic insights.Genetics · 2021Article
- Inferring Parameters of the Distribution of Fitness Effects of New Mutations When Beneficial Mutations Are Strongly Advantageous and Rare.G3 (Bethesda, Md.) · 2020Article
- Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals.PLoS genetics · 2020Article
- Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio ω for Closely Related Species.Molecular biology and evolution · 2020Article
- Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog.Genetics · 2019Article
- Removal of alleles by genome editing (RAGE) against deleterious load.Genetics, selection, evolution : GSE · 2019Article
- Molecular Population Genetics.Genetics · 2017Review
- DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.Heredity · 2017Article
- Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence.Interface focus · 2015Article
- The evolutionarily stable distribution of fitness effects.Genetics · 2015Article
- Article
- Review
- Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.PLoS genetics · 2014Article
- Background selection as baseline for nucleotide variation across the Drosophila genome.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The properties of the distribution of deleterious mutational effects on fitness (DDME) are of fundamental importance for evolutionary genetics. Since it is extremely difficult to determine the nature of this distribution, several methods using various assumptions about the DDME have been developed, for the purpose of parameter estimation. We apply a newly developed method to DNA sequence polymorphism data from two Drosophila species and compare estimates of the parameters of the distribution of the heterozygous fitness effects of amino acid mutations for several different distribution functions. The results exclude normal and gamma distributions, since these predict too few effectively lethal mutations and power-law distributions as a result of predicting too many lethals. Only the lognormal distribution appears to fit both the diversity data and the frequency of lethals. This DDME arises naturally in complex systems when independent factors contribute multiplicatively to an increase in fitness-reducing damage. Several important parameters, such as the fraction of effectively neutral non-synonymous mutations and the harmonic mean of non-neutral selection coefficients, are robust to the form of the DDME. Our results suggest that the majority of non-synonymous mutations in Drosophila are under effective purifying selection.
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