ArticleProceedings. Biological sciences2007
The cost of replication fidelity in human immunodeficiency virus type 1.
Article in Proceedings. Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- RNA life on the edge of catastrophe.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A New HIV-1 KMicrobiology spectrum · 2022Article
- Within-Host Viral Diversity: A Window into Viral Evolution.Annual review of virology · 2020Review
- Low mutation rates promote the evolution of advantageous traits by preventing interference from deleterious mutations.Genetica · 2020Article
- Article
- Article
- Chikungunya Virus Fidelity Variants Exhibit Differential Attenuation and Population Diversity in Cell Culture and Adult Mice.Journal of virology · 2019Article
- A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus.PLoS biology · 2018Article
- Fidelity Variants and RNA Quasispecies.Current topics in microbiology and immunology · 2016Review
- Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes.PLoS pathogens · 2015Article
- Connecting within-host dynamics to the rate of viral molecular evolution.Virus evolution · 2015Article
- Review
- Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models.PLoS pathogens · 2014Article
- Correlation between mutation rate and genome size in riboviruses: mutation rate of bacteriophage Qβ.Genetics · 2013Article
- Evaluating evolutionary models of stress-induced mutagenesis in bacteria.Nature reviews. Genetics · 2013Review
- Interrelationship between HIV-1 fitness and mutation rate.Journal of molecular biology · 2013Article
- Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.Proceedings. Biological sciences · 2013Article
- The lower bound to the evolution of mutation rates.Genome biology and evolution · 2011Article
- Fidelity in archaeal information processing.Archaea (Vancouver, B.C.) · 2010Review
- The relationship between mutation frequency and replication strategy in positive-sense single-stranded RNA viruses.Proceedings. Biological sciences · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation rates should be governed by at least three evolutionary factors: the need for beneficial mutations, the benefit of minimizing the mutational load and the cost of replication fidelity. RNA viruses show high mutation rates compared with DNA micro-organisms, and recent findings suggest that the cost of fidelity might play a role in the evolution of increased mutation rates. Here, by analysing previously published data from HIV-1 reverse transcriptase in vitro assays, we show a trade-off between enzymatic accuracy and the maximum rate of polymerization, thus providing a biochemical basis for the fitness cost of fidelity in HIV-1. This trade-off seems to be related to inefficient extension of mispairs, which increases fidelity at the expense of the polymerization rate. Since in RNA viruses fast replication is critical for survival, this could impose a high cost of fidelity and favour the evolution of high mutation rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.