ArticleBreast cancer research : BCR2006
Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy.
Article in Breast cancer research : BCR, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Guideline
- Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.BMJ (Clinical research ed.) · 2015Pooled it
- Screening for breast cancer: an update for the U.S. Preventive Services Task Force.Annals of internal medicine · 2009Pooled it
- Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends.BMJ (Clinical research ed.) · 2009Pooled it
- Cancer survival in Lower Silesia: insights from a national oncology network pilot in Poland.Frontiers in oncology · 2026Article
- Identification of the Fraction of Indolent Tumors and Associated Overdiagnosis in Breast Cancer Screening Trials.American journal of epidemiology · 2019Article
- Recognizing the Limitations of Cancer Overdiagnosis Studies: A First Step Towards Overcoming Them.Journal of the National Cancer Institute · 2016Review
- Overdiagnosis: epidemiologic concepts and estimation.Epidemiology and health · 2015Article
- Potential overuse of screening mammography and its association with access to primary care.Medical care · 2014Article
- Predicting life expectancy for community-dwelling older adults from Medicare claims data.American journal of epidemiology · 2013Article
- Overdiagnosis among women attending a population-based mammography screening program.International journal of cancer · 2013Article
- The benefits and harms of breast cancer screening: an independent review.British journal of cancer · 2013Review
- Influence of study features and methods on overdiagnosis estimates in breast and prostate cancer screening.Annals of internal medicine · 2013Review
- Refining physician quality indicators for screening mammography in older women: distinguishing appropriate use from overuse.Journal of the American Geriatrics Society · 2013Article
- Article
- Balancing harms and benefits of service mammography screening programs: a cohort study.Breast cancer research : BCR · 2012Article
- Overdiagnosis from non-progressive cancer detected by screening mammography: stochastic simulation study with calibration to population based registry data.BMJ (Clinical research ed.) · 2011Article
- Breast cancer screening with mammography.Current oncology reports · 2011Review
- Interpreting overdiagnosis estimates in population-based mammography screening.Epidemiologic reviews · 2011Review
- Breast cancer incidence and overdiagnosis in Catalonia (Spain).Breast cancer research : BCR · 2010Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExcess of incidence rates is the expected consequence of service screening. The aim of this paper is to estimate the quota attributable to overdiagnosis in the breast cancer screening programmes in Northern and Central Italy.
methodsAll patients with breast cancer diagnosed between 50 and 74 years who were resident in screening areas in the six years before and five years after the start of the screening programme were included. We calculated a corrected-for-lead-time number of observed cases for each calendar year. The number of observed incident cases was reduced by the number of screen-detected cases in that year and incremented by the estimated number of screen-detected cases that would have arisen clinically in that year.
resultsIn total we included 13,519 and 13,999 breast cancer cases diagnosed in the pre-screening and screening years, respectively. In total, the excess ratio of observed to predicted in situ and invasive cases was 36.2%. After correction for lead time the excess ratio was 4.6% (95% confidence interval 2 to 7%) and for invasive cases only it was 3.2% (95% confidence interval 1 to 6%).
conclusionThe remaining excess of cancers after individual correction for lead time was lower than 5%.
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