ArticleJournal of brachial plexus and peripheral nerve injury2006
Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rats.
Article in Journal of brachial plexus and peripheral nerve injury, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Comparison of the Effects of Perineural and Intraperitoneal Ozone Therapy on Nerve Healing in an Experimental Sciatic Nerve Injury Model.Medicina (Kaunas, Lithuania) · 2024Article
- High-Fat and High-Sucrose Diet Leads to Skeletal Muscle Loss and Bladder Dysfunction in Rat.Research and reports in urology · 2023Article
- Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury.Neural regeneration research · 2016Article
- Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats.Bosnian journal of basic medical sciences · 2015Article
- Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat.Iranian journal of basic medical sciences · 2015Article
- Crocin enhanced functional recovery after sciatic nerve crush injury in rats.Iranian journal of basic medical sciences · 2013Article
- Effect of ischemia/reperfusion on bladder nerve and detrusor cell damage.International urology and nephrology · 2009Article
- Regenerative Potential of Platelet-Rich Fibrin Releasate Combined with Adipose Tissue-Derived Stem Cells in a Rat Sciatic Nerve Injury Model.Cell transplantationArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimAllow for protection of briefly ischemic tissues against the harmful effects of subsequent prolonged ischemia is a phenomenon called as Ischemic Preconditioning (IP). IP has not been studied in ischemia-reperfusion (I/R) model of peripheral nerve before. We aimed to study the effects of acute IP on I/R injury of peripheral nerve in rats.
method70 adult male rats were randomly divided into 5 groups in part 1 experimentation and 3 groups in part 2 experimentation. A rat model of severe nerve ischemia which was produced by tying iliac arteries and all identifiable anastomotic vessels with a silk suture (6-0) was used to study the effects of I/R and IP on nerve biochemistry. The suture technique used was a slip-knot technique for rapid release at time of reperfusion in the study. Cytoplasmic vacuolar degeneration was also histopathologically evaluated by light microscopic examination in sciatic nerves of rats at 7th day in part 2 study.
results3 hours of Reperfusion resulted in an increase in nerve malondialdehyde levels when compared with ischemia and non-ischemia groups (p < 0.001 and p < 0.0001 respectively). IP had significantly lower nerve MDA levels than 3 h reperfusion group (p < 0.001). The differences between ischemic, IP and non-ischemic control groups were not significant (p > 0.05). There was also a significant decrease in vacuolar degeneration of sciatic nerves in IP group than I/R group (p < 0.05).
conclusionIP reduces the severity of I/R injury in peripheral nerve as shown by reduced tissue MDA levels at 3rd hour of reperfusion and axonal vacuolization at 7th postischemic day.
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Registered trials
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