ArticleAIDS research and human retroviruses2006
Modulation of osteoclastogenesis induced by nucleoside reverse transcriptase inhibitors.
Article in AIDS research and human retroviruses, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Timing, Dosage, and Adherence of Antiretroviral Therapy and Risk of Osteoporosis in Patients With Human Immunodeficiency Virus Infection in Taiwan: A Nested Case-Control Study.Frontiers in pharmacology · 2021Article
- CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life.The Journal of clinical endocrinology and metabolism · 2017Article
- The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis.Scientifica · 2013Review
- HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection.Journal of osteoporosis · 2013Review
- Bone disease in HIV infection.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2011Article
- Bone changes and fracture risk in individuals infected with HIV.Current rheumatology reports · 2010Review
- Is PPARγ a prospective player in HIV-1-associated bone disease?PPAR research · 2009Article
- [Metabolic bone diseases].Der Internist · 2007Article
- Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS.Annals of the New York Academy of Sciences · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Osteopenia is a common and debilitating side-effect of HAART, yet little is known concerning the effects of HAART on bone metabolism. We reported previously that zidovudine (AZT) stimulates osteoclastogenesis in vitro and causes osteopenia in mice. Here, we confirmed that the AZT-induced osteoclastogenesis is dependent on RANKL in that osteoclastogenesis is blocked by osteoprotegestin. Alendronate, which is used for the treatment of osteopenia and osteoporosis, failed to inhibit AZT-induced osteoclastogenesis in vitro. Osteoclastogenesis in vitro was not affected by tumor necrosis factor-alpha. Two other NRTI drugs, ddl and 3TC, also induced osteoclastogenesis in vitro and induced osteopenia in mice. The osteopenia was associated with an elevation of parameters of osteoclasts, but not with osteoblasts. Combinations of the NRTIs did not result in additive or synergistic effects in vitro or in vivo. Finally, AZT induced osteoclastogenesis of human osteoclast precursors in a RANKL-dependent manner. This in vitro osteoclastogenesis assay using human peripheral blood mononuclear cells could be useful in evaluating bone turnover and the risk of developing osteopenia in AIDS patients on HAART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.