SynthesisDrug safety2006
Statins and pancreatitis: a systematic review of observational studies and spontaneous case reports.
Synthesis in Drug safety, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Systematic reviews of adverse effects: framework for a structured approach.BMC medical research methodology · 2007Pooled it
- Clinical characteristics, diagnosis and prognosis of statin-induced acute pancreatitis.Internal and emergency medicine · 2026Article
- Lipid-core nanocapsules containing simvastatin do not affect the biochemical and hematological indicators of toxicity in rats.Toxicology research · 2024Article
- Article
- Statins exposure and acute pancreatitis: a retrospective cohort study using a large national insurance database.BMJ open · 2023Article
- Article
- Article
- Ever-increasing diversity of drug-induced pancreatitis.World journal of gastroenterology · 2020Review
- Acute pancreatitis as a complication of routine colonoscopy-A rare case report.International journal of surgery case reports · 2019Article
- Article
- Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies.United European gastroenterology journal · 2018Article
- Different effects of statins on induction of diabetes mellitus: an experimental study.Drug design, development and therapy · 2015Article
- Statins and their role in acute pancreatitis: Case report and literature review.World journal of gastrointestinal pharmacology and therapeutics · 2014Article
- Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources.Therapeutic advances in drug safety · 2011Review
- Atorvastatin-induced acute pancreatitis.Journal of pharmacology & pharmacotherapeutics · 2011Article
- Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials.British journal of clinical pharmacology · 2009Article
- Drug-induced pancreatitis : incidence, management and prevention.Drug safety · 2008Review
- Drug-induced acute pancreatitis.Proceedings (Baylor University. Medical Center) · 2008Article
- Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2008Review
- New advances in acute pancreatitis.Current opinion in gastroenterology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many anecdotal reports have suggested that therapy with HMG-CoA reductase inhibitors ('statins') can cause acute pancreatitis. We aimed to quantify the association between statins and pancreatitis and to classify the adverse effect under the dose, time, susceptibility (DoTS) system. We searched for controlled observational studies that assessed the risk of pancreatitis in patients receiving statins. In order to identify case reports of statin-induced pancreatitis, we looked for reports published in scientific journals and manually reviewed reports within the Canadian Adverse Drug Event Monitoring System (CADRMP) database. Two observational studies were identified and the data pooled together in a meta-analysis. This yielded an odds ratio of 1.41 (95% CI 1.15, 1.74) for the risk of acute pancreatitis in patients with a past history of exposure to statins. We also identified 20 published case reports and 33 spontaneous reports from the CADRMP database. These data showed that pancreatitis can occur at both high and low doses, with 12 cases developing pancreatitis at less than the dose equivalent of simvastatin 20 mg daily. Statin-induced pancreatitis can occur at any time but seems to be very uncommon early on and more likely to occur after many months of therapy. There does not appear to be a cumulative dose effect and increasing age does not appear to be a major susceptibility factor. These finding should help clinicians to better manage and diagnose patients who are at risk of statin-induced pancreatitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.