ArticleGlycoconjugate journal2007
In vitro antileishmanial activity of Aloe vera leaf exudate: a potential herbal therapy in leishmaniasis.
Article in Glycoconjugate journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 49 citations in OpenAlex.
- Development, characterization, and anti-leishmanial activity of topical amphotericin B nanoemulsions.Drug delivery and translational research · 2020Article
- Antioxidant, Antimicrobial, Cytotoxic, and Protein Kinase Inhibition Potential inBioMed research international · 2019Article
- Ethanolic leaf extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2017Review
- Antileishmanial Activities of Greek Juniper (Juniperus excelsa M.Bieb.) Against Leishmania major Promastigotes.Journal of evidence-based complementary & alternative medicine · 2017Article
- Tamoxifen Induces Apoptosis of Leishmania major Promastigotes in Vitro.The Korean journal of parasitology · 2016Article
- In vitro and in vivo antileishmanial effects of aloe-emodin on Leishmania major.Journal of traditional and complementary medicine · 2015Article
- Antileishmanial activity of medicinal plants used in endemic areas in northeastern Brazil.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- The Effect of Garlic Extract on Expression of INFγ And Inos Genes in Macrophages Infected with Leishmania major.Iranian journal of parasitology · 2011Article
- 9-O-acetylated sialoglycoproteins are important immunomodulators in Indian visceral leishmaniasis.Clinical and vaccine immunology : CVI · 2009Article
- In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis.Parasitology research · 2008Article
- An ethanolic extract of leaves of Piper betle (Paan) Linn mediates its antileishmanial activity via apoptosis.Parasitology research · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC(50) ranged from 100 to 180 microg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC(50) was 6.0 microg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations.
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