ArticlePediatric nephrology (Berlin, Germany)2007
Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The efficacy and safety of rituximab in treating childhood refractory nephrotic syndrome: a meta-analysis.Scientific reports · 2015Pooled it
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: medical therapy.Clinical and experimental nephrology · 2015Guideline
- Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis.Pediatric nephrology (Berlin, Germany) · 2013Trial
- Challenging Clinical Practice Guideline Definitions in Childhood Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Efficacy of Calcineurin Inhibition in Children With Steroid-Resistant Nephrotic Syndrome.Kidney international reports · 2025Article
- Efficacy of rituximab and risk factors for poor prognosis in patients with childhood-onset steroid-resistant nephrotic syndrome: a multicenter study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Efficacy and Safety of Immunosuppressive Therapy in Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-analysis.Kidney medicine · 2022Article
- Clinicopathological spectrum and treatment outcome of idiopathic steroid-resistant nephrotic syndrome in children at a tertiary care center.Medical journal, Armed Forces India · 2022Article
- Exploring the Clinical and Genetic Spectrum of Steroid Resistant Nephrotic Syndrome: The PodoNet Registry.Frontiers in pediatrics · 2018Review
- Long-Term Outcome of Steroid-Resistant Nephrotic Syndrome in Children.Journal of the American Society of Nephrology : JASN · 2017Article
- The non-immunosuppressive management of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2016Review
- Long-term Outcomes of Childhood Onset Nephrotic Syndrome.Frontiers in pediatrics · 2016Review
- Association of neutrophil gelatinase associated lipocalin and cystatin-C with kidney function in children with nephrotic syndrome.International journal of preventive medicine · 2013Article
- Ankle brachial index in children with steroid-resistant nephrotic syndrome.Sultan Qaboos University medical journal · 2013Article
- The expression of cytoskeletal proteins in kidney specimens of children with primary focal segmental glomerulosclerosis.Indian journal of nephrology · 2012Article
- Problems with 'focal segmental glomerulosclerosis'.Pediatric nephrology (Berlin, Germany) · 2011Review
- New therapies in steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2011Review
- Efficacy and safety of treatment with rituximab for difficult steroid-resistant and -dependent nephrotic syndrome: multicentric report.Clinical journal of the American Society of Nephrology : CJASN · 2010Article
- C1q nephropathy in the pediatric population: pathology and pathogenesis.Pediatric nephrology (Berlin, Germany) · 2010Review
- Long-term outcome of idiopathic steroid-resistant nephrotic syndrome: a multicenter study.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Clinical and histological data of children presenting with steroid-resistant nephrotic syndrome and renal biopsy showing focal and segmental glomerulosclerosis from 1980 with a follow-up of over 10 years were reviewed. There were 66 patients; 38 male and 28 female. Age at onset ranged from 0.4-14.1 years (mean 6.4). Tubular atrophy was present at first biopsy in 50/66, capsular adhesions in 35/66, glomerular tip lesions in 8/66 and mesangial expansion in 31/66 patients. In 51 children, cyclophosphamide was prescribed as the first cytotoxic agent, while 15 received cyclosporine A and complete remission was induced in 43 and 40% of the children, respectively. Complete and stable remission was maintained in 35 children, while 22 had reduction of proteinuria with symptomatic relief. Nine were refractory to cytotoxic therapy. Of the 35 patients who entered complete and stable remission, the renal survival was over 90%, while in the 31 non-responders it was 48% in 10 years. The multivariate analysis using unconditional logistic regression method identified the presence of mesangial expansion (p=0.011) and tip lesions (p=0.005) as the independent predictors of favourable response to cytotoxic therapy and the presence of renal impairment (p=0.008) and extensive focal segmental sclerosis (p=0.025) as independent predictors of unfavourable response.
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