ArticleMolecular genetics and genomics : MGG2007
Gene expression dynamics in deer antler: mesenchymal differentiation toward chondrogenesis.
Article in Molecular genetics and genomics : MGG, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Views on Antlers Then and Now: Past and Present Concepts of Their Development and Histogenesis.Animals : an open access journal from MDPI · 2026Review
- TheBiology · 2025Article
- MiRNA Profiling and Its Potential Roles in Rapid Growth of Velvet Antler in Gansu Red Deer (Genes · 2023Article
- Evaluation of candidate reference genes for quantitative real-time PCR normalization in blood from red deer developing antlers.Scientific reports · 2022Article
- Exogenous Melatonin Activating Nuclear Factor E2-Related Factor 2 (Nrf2) Pathway via Melatonin Receptor to Reduce Oxidative Stress and Apoptosis in Antler Mesenchymal Stem Cells.Molecules (Basel, Switzerland) · 2022Article
- Parentage testing and looking for single nucleotide markers associated with antler quality in deer (Archives animal breeding · 2022Article
- Integrated analysis of miRNA and mRNA transcriptomic reveals antler growth regulatory network.Molecular genetics and genomics : MGG · 2021Article
- New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration.Journal of orthopaedic translation · 2021Review
- Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth.Cellular & molecular biology letters · 2020Article
- Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler.International journal of genomics · 2020Article
- Mining the red deer genome (CerEla1.0) to develop X-and Y-chromosome-linked STR markers.PloS one · 2020Article
- Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon).BMC genomics · 2019Article
- Article
- Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq.Stem cell research & therapy · 2018Article
- The red deer Cervus elaphus genome CerEla1.0: sequencing, annotating, genes, and chromosomes.Molecular genetics and genomics : MGG · 2018Article
- The Regulatory Mechanism of MLT/MT1 Signaling on the Growth of Antler Mesenchymal Cells.Molecules (Basel, Switzerland) · 2017Article
- Transcriptome analysis of sika deer in China.Molecular genetics and genomics : MGG · 2016Article
- Direct localisation of molecules in tissue sections of growing antler tips using MALDI imaging.Molecular and cellular biochemistry · 2015Article
- Proteomes and signalling pathways of antler stem cells.PloS one · 2012Article
- Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus: expression dynamics for regulatory and effector genes.Molecular genetics and genomics : MGG · 2010Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Annual re-growth of deer antler represents a unique example of complete organ regeneration. Because antler mesenchymal cells retain their embryonic capacity to develop into cartilage or bone, studying antler development provides a natural system to follow gene expression changes during mesenchymal differentiation toward chondrogenic/osteogenic lineage. To identify novel genes involved either in early events of mesenchymal cell specialization or in robust bone development, we have introduced a 3 K heterologous microarray set-up (deer cDNA versus mouse template). Fifteen genes were differentially expressed; genes for housekeeping, regulatory functions (components of different signaling pathways, including FGF, TGFbeta, Wnt), and genes encoding members of the Polycomb group were represented. Expression dynamics for genes are visualized by an expression logo. The expression profile of the gene C21orf70 of unknown function is described along with the effects when over-expressed; furthermore the nuclear localization of the cognate protein is shown. In this report, we demonstrate the particular advantage of the velvet antler model in bone research for: (1) identification of mesenchymal and precartilaginous genes and (2) targeting genes upregulated in robust cartilage development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.