ArticleHuman genetics2007
The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Factors Affecting Menstrual Cycle Developmental Trajectory in Adolescents: A Narrative Review.International journal of endocrinology and metabolism · 2022Review
- Sharing of Genes and Pathways Across Complex Phenotypes: A Multilevel Genome-Wide Analysis.Genetics · 2017Article
- Genome-wide copy number variation association analyses for age at menarche.The Journal of clinical endocrinology and metabolism · 2012Article
- The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin.Human reproduction (Oxford, England) · 2011Article
- A large-scale candidate gene association study of age at menarche and age at natural menopause.Human genetics · 2010Article
- Association weight matrix for the genetic dissection of puberty in beef cattle.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii.Cancer causes & control : CCC · 2010Article
- Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.PLoS genetics · 2009Article
- Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.The Journal of clinical endocrinology and metabolism · 2008Article
- Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women.Menopause (New York, N.Y.)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Chemokine (C-C-motif) receptor 3 (CCR3), playing an important role in endometrium related metabolic pathways, may influence the onset of menarche. To test linkage and/or association between CCR3 polymorphisms with the variation of age at menarche (AAM) in Caucasian females, we recruited a sample of 1,048 females from 354 Caucasian nuclear families and genotyped 16 SNPs spanning the entire CCR3 gene. Linkage disequilibrium and haplotype blocks were inferred by Haploview. Both single-SNP markers and haplotypes were tested for linkage and/or association with AAM using QTDT (quantitative transmission disequilibrium test). We also tested associations between CCR3 polymorphisms and AAM in a selected random sample of daughters using ANOVA (analysis of variance). We identified two haplotype blocks. Only block two showed significant results. After correction for multiple testing, significant total associations of SNP7, SNP9 with AAM were detected (P = 0.009 and 0.006, respectively). We also detected significant within-family association of SNP9 (P = 0.01). SNP14 was linked to AAM (P = 0.02) at the nominal level. In addition, there was evidence of significant total association and nominal significant linkage (P = 0.008 and 0.03, respectively) with AAM for the haplotype AGA reconstructed by SNP7, SNP9 and SNP13. ANOVA confirmed the results by QTDT. For the first time we reported that CCR3 is linked and associated with AAM variation in Caucasian women. However, further studies are necessary to substantiate our conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.