ArticleBritish journal of cancer2006
Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis.Frontiers in cell and developmental biology · 2022Review
- In situ neutrophil efferocytosis shapes T cell immunity to influenza infection.Nature immunology · 2020Article
- Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression.Frontiers in cell and developmental biology · 2020Review
- Syncytin 1 dependent horizontal transfer of marker genes from retrovirally transduced cells.Scientific reports · 2019Article
- Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system.Cellular and molecular life sciences : CMLS · 2015Article
- Phagocytosis (cannibalism) of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas.World journal of gastroenterology · 2015Article
- Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples.PLoS computational biology · 2013Article
- Article
- Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.The Journal of biological chemistry · 2012Article
- Article
- Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.PloS one · 2011Article
- Uptake of foreign nucleic acids in kidney tubular epithelial cells deficient in proapoptotic endonucleases.DNA and cell biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously it was shown that horizontal DNA transfer between mammalian cells can occur through the uptake of apoptotic bodies, where genes from the apoptotic cells were transferred to neighbouring cells phagocytosing the apoptotic bodies. The regulation of this process is poorly understood. It was shown that the ability of cells as recipient of horizontally transferred DNA was enhanced by deficiency of p53 or p21. However, little is known with regard to the regulation of DNA from donor apoptotic cells. Here we report that the DNA fragmentation factor/caspase-activated DNase (DFF/CAD), which is the endonuclease responsible for DNA fragmentation during apoptosis, plays a significant role in regulation of horizontal DNA transfer. Cells with inhibited DFF/CAD function are poor donors for horizontal gene transfer (HGT) while their ability of being recipients of HGT is not affected.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.