Evidence map›Paper›PMID 17146470›Full record

SynthesisMolecular psychiatry2007

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients.

A Serretti, M Kato, D De Ronchi, T Kinoshita

Registry-linked trialAbstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02411123 (Prospective Randomized Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders), which is not on this map. Cited by 166 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 11 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02411123 nacompletednot on this mapstarted 2015, after this paper: background citation

Prospective Randomized Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders

TypeinterventionalSponsorAltheaDxRan2015 to 2015Enrolled220ConditionsDepression, AnxietyArmsIDgenetix Neuropsychiatric Test Panel
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 11 syntheses or guidelines pooled it, 530 citations in OpenAlex.

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  14. Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism.Journal of child and adolescent psychopharmacology · 2015
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  16. SLC6A4 polymorphisms and age of onset in late-life depression on treatment outcomes with citalopram: a Sequenced Treatment Alternatives to Relieve Depression (STAR*D) report.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014
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  19. Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2011
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

A SerrettiInstitute of Psychiatry, University of Bologna, Bologna, Italy. alessandro.serretti@unibo.it
M Kato
D De Ronchi
T Kinoshita
University of Bologna · ITKansai Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4 weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (P<0.0001) and both s/s and s/l variants with response rate (P=0.0002). Response rate within 4 weeks was associated in both models (P=0.003-P<0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples.

Indexed as

Polymorphism, GeneticPromoter Regions, GeneticAdultAgedDepressive DisorderFemaleHumansMaleMEDLINEMiddle AgedSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID17146470
OpenAlexW1982886582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.