ArticleOncogene2007
PML4 induces differentiation by Myc destabilization.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer.Cell death and differentiation · 2024Article
- Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NADNature structural & molecular biology · 2017Article
- Article
- Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.PloS one · 2015Article
- A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation.PLoS genetics · 2014Article
- Article
- Cellular senescence and protein degradation: breaking down cancer.Cell cycle (Georgetown, Tex.) · 2014Article
- Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.Cell cycle (Georgetown, Tex.) · 2013Article
- Differential Roles of PML Isoforms.Frontiers in oncology · 2013Article
- MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.Molecular and cellular biology · 2012Article
- E-box-independent regulation of transcription and differentiation by MYC.Nature cell biology · 2011Article
- Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1.The Journal of biological chemistry · 2010Article
- PML: An emerging tumor suppressor and a target with therapeutic potential.Cancer therapy · 2009Article
- Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies.International journal of biological sciences · 2009Review
- Regulation of apoptosis by PML and the PML-NBs.Oncogene · 2008Review
- MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.Molecular and cellular biology · 2008Article
- Article
- Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.Molecular and cellular biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opposing functions like oncogene and tumor suppressions have been established for c-Myc and promyelocytic leukemia (PML) protein, respectively. Myc is known to inhibit differentiation of hematopoietic precursor cells, and here we report that PML promotes cell differentiation. We further demonstrate that PML and Myc form a complex in vivo. The interaction of the two proteins leads to the destabilization of Myc in a manner dependent on the really interesting new gene (RING) domain of PML. Although several PML isoforms are able to interact with Myc, the ability to destabilize Myc is specific for PML4. Importantly, the PML-induced destabilization resulted in a reduction of promoter-bound Myc on Myc-repressed genes. Thereby, PML induced the re-activation of Myc-repressed target genes including the tumor suppressive genes of the cell cycle inhibitors cdkn1a/p21 and cdkn2b/p15. Together, these results establish PML-mediated destabilization of Myc and the derepression of cell cycle inhibitor genes as an important regulatory mechanism that allows cell differentiation and prevents aberrant proliferation driven by uncontrolled Myc activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.