ArticleProceedings of the National Academy of Sciences of the United States of America1991
Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay.PLoS biology · 2025Article
- Age-dependent small fiber neuropathy: Mechanistic insights from animal models.Experimental neurology · 2024Review
- Structural aspects of the aging invertebrate brain.Cell and tissue research · 2021Review
- Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application.Current neuropharmacology · 2018Review
- Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.PLoS biology · 2017Article
- Neuronal epigenetics and the aging synapse.Frontiers in cellular neuroscience · 2015Review
- Communication breakdown: the impact of ageing on synapse structure.Ageing research reviews · 2014Review
- Insights into CNS ageing from animal models of senescence.Nature reviews. Neuroscience · 2012Review
- Cyclic adenosine monophosphate metabolism in synaptic growth, strength, and precision: neural and behavioral phenotype-specific counterbalancing effects between dnc phosphodiesterase and rut adenylyl cyclase mutations.Journal of neurogenetics · 2012Article
- Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regional calcium regulation within cultured Drosophila neurons: effects of altered cAMP metabolism by the learning mutations dunce and rutabaga.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram.Learning & memory (Cold Spring Harbor, N.Y.) · 2000Article
- Single neuron mosaics of the drosophila gigas mutant project beyond normal targets and modify behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Altered habituation of an identified escape circuit in Drosophila memory mutants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several mutations in Drosophila impair learning and the cAMP cascade. We report here that the fine morphology of an identified mechanosensory neuron is abnormal in two of these mutants, dunce (dnc) and rutabaga (rut). The neuron innervating the antero-notopleural bristle was filled with horseradish peroxidase and studied at the light- and electron-microscopy level. In the mutants dnc and rut, this neuron has an abnormally large number of side branches and varicosities in a defined segment of the axon. In wild-type flies, age tends to decrease the number of side branches and variacosities in the same axonal segment that is affected by the mutations. Ultrastructural studies are compatible with the interpretation that the varicosities are potential synaptic sites. The results suggest that the cAMP cascade plays a role in shaping neuronal connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.