ArticleInfection and immunity2007
The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Differential Transcriptional Responses of Human Granulocytes to Fungal Infection withJournal of fungi (Basel, Switzerland) · 2023Article
- The effect of antifungal resistance development on the virulence of Candida species.FEMS yeast research · 2022Article
- Review
- Survival Strategies of PathogenicmBio · 2020Article
- Neutrophils in innate immunity and systems biology-level approaches.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Article
- Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.Nature immunology · 2019Article
- Article
- An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy.Frontiers in microbiology · 2016Review
- How to Predict Molecular Interactions between Species?Frontiers in microbiology · 2016Review
- Challenges and Strategies for Proteome Analysis of the Interaction of Human Pathogenic Fungi with Host Immune Cells.Proteomes · 2015Review
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Multi-step pathogenesis and induction of local immune response by systemic Candida albicans infection in an intravenous challenge mouse model.International journal of molecular sciences · 2014Article
- Candida albicans biofilms do not trigger reactive oxygen species and evade neutrophil killing.The Journal of infectious diseases · 2012Article
- Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling.Medical mycology · 2011Article
- Massive induction of innate immune response to Candida albicans in the kidney in a murine intravenous challenge model.FEMS yeast research · 2009Article
- Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.Infection and immunity · 2008Article
- Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component.Cell host & microbe · 2007Article
- Role of neutrophils in innate immunity: a systems biology-level approach.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans is a polymorphic opportunistic fungus that can cause life-threatening systemic infections following hematogenous dissemination in patients susceptible to nosocomial infection. Neutrophils form part of the innate immune response, which is the first line of defense against microbes and is particularly important in C. albicans infections. To compare the transcriptional response of leukocytes exposed to C. albicans, we investigated the expression of key cytokine genes in polymorphonuclear and mononuclear leukocytes after incubation with C. albicans for 1 h. Isolated mononuclear cells expressed high levels of genes encoding proinflammatory signaling molecules, whereas neutrophils exhibited much lower levels, similar to those observed in whole blood. The global transcriptional profile of neutrophils was examined by using an immunology-biased human microarray to determine whether different morphological forms or the viability of C. albicans altered the transcriptome. Hyphal cells appeared to have the broadest effect, although the most strongly induced genes were regulated independently of morphology or viability. These genes were involved in proinflammatory cell-cell signaling, cell signal transduction, and cell growth. Generally, genes encoding known components of neutrophil granules showed no upregulation at this time point; however, lactoferrin, a well-known candidacidal peptide, was secreted by neutrophils. Addition to inhibitors of RNA or protein de novo synthesis did not influence the killing activity within 30 min. These results support the general notion that neutrophils do not require gene transcription to mount an immediate and direct attack against microbes. However, neutrophils exposed to C. albicans express genes involved in communication with other immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.