ArticleProceedings of the National Academy of Sciences of the United States of America1991
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 154 citations in OpenAlex.
- Review
- High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair.The Journal of biological chemistry · 2022Review
- Nerve Growth Factor Signaling and Its Contribution to Pain.Journal of pain research · 2020Review
- Article
- Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.Neurobiology of disease · 2018Article
- Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration.Neural regeneration research · 2017Review
- Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.Journal of neurochemistry · 2014Article
- Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.BMC neuroscience · 2014Article
- p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.American journal of physiology. Heart and circulatory physiology · 2008Article
- Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling.The Biochemical journal · 2005Article
- Brain metastases in melanoma: roles of neurotrophins.Neuro-oncology · 2004Review
- Brain-metastatic melanoma: a neurotrophic perspective.Pathology oncology research : POR · 2003Review
- Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line.Journal of virology · 1997Article
- Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors.British journal of pharmacology · 1996Article
- p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase.The EMBO journal · 1996Article
- Article
- Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.Immunologic research · 1996Review
- Trophic factors and central nervous system metastasis.Cancer metastasis reviews · 1995Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Protein tyrosine phosphorylation is a potential mechanism for initial signaling in PC12 cells during differentiation in response to nerve growth factor (NGF). NGF-induced tyrosine phosphorylation has been found to be initiated by the trk protooncogene, which participates in the formation of high-affinity NGF binding sites. In contrast to transfection of wild-type low-affinity p75 NGF receptors, transfection of p75NGFR with mutations in the cytoplasmic domain resulted in an inability of NGF to elicit tyrosine phosphorylation of intracellular substrates, indicating that p75NGFR is involved in initiating phosphorylation events by NGF. Even though the p75NGFR receptor does not possess any inherent tyrosine kinase activity, these experiments demonstrate that the p75NGFR has a potential role in NGF-induced tyrosine phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.