ArticleMolecular and cellular biology2007
Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Systematic analysis of apoptosis-related genes in the prognosis of lung squamous cell carcinoma: a combined single-cell RNA sequencing study.Journal of thoracic disease · 2023Article
- Exploring the mechanism of ellagic acid against gastric cancer based on bioinformatics analysis and network pharmacology.Journal of cellular and molecular medicine · 2023Article
- Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.Frontiers in oncology · 2023Article
- The Renaissance of CDK Inhibitors in Breast Cancer Therapy: An Update on Clinical Trials and Therapy Resistance.Cancers · 2022Review
- Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility.International journal of molecular sciences · 2021Article
- Anti-Müllerian hormone inhibits proliferation and induces apoptosis in epithelial ovarian cancer cells by regulating the cell cycle and decreasing the secretion of stem cell factor.Oncology letters · 2018Article
- Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells.Cell death & disease · 2016Article
- The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.Cancer research · 2015Article
- BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion.Experimental cell research · 2015Article
- Mammary gland selective excision of c-jun identifies its role in mRNA splicing.Cancer research · 2012Article
- PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b.Cell cycle (Georgetown, Tex.) · 2011Article
- C-jun inhibits mammary apoptosis in vivo.Molecular biology of the cell · 2010Article
- The role of signaling pathways in the expansion of corneal epithelial cells in serum-free B27 supplemented medium.Molecular vision · 2010Article
- microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.The Journal of biological chemistry · 2010Article
- Emerging roles of ATF2 and the dynamic AP1 network in cancer.Nature reviews. Cancer · 2010Review
- Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.The American journal of pathology · 2009Article
- Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.Molecular biology of the cell · 2008Article
- Akt1 governs breast cancer progression in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cancer cells arise through sequential acquisition of mutations in tumor suppressors and oncogenes. c-Jun, a critical component of the AP-1 complex, is frequently overexpressed in diverse tumor types and has been implicated in promoting cellular proliferation, migration, and angiogenesis. Functional analysis of candidate genetic targets using germ line deletion in murine models can be compromised through compensatory mechanisms. As germ line deletion of c-jun induces embryonic lethality, somatic deletion of the c-jun gene was conducted using floxed c-jun (c-jun(f/f)) conditional knockout mice. c-jun-deleted cells showed increased cellular adhesion, stress fiber formation, and reduced cellular migration. The reduced migratory velocity and migratory directionality was rescued by either c-Jun reintroduction or addition of secreted factors from wild-type cells. An unbiased analysis of cytokines and growth factors, differentially expressed and showing loss of secretion upon c-jun deletion, identified stem cell factor (SCF) as a c-Jun target gene. Immunoneutralizing antibody to SCF reduced migration of wild-type cells. SCF addition rescued the defect in cellular adhesion, cellular velocity, directional migration, transwell migration, and cellular invasion of c-jun(-/-) cells. c-Jun induced SCF protein, mRNA, and promoter activity. Induction of the SCF promoter required the c-Jun DNA-binding domain. c-Jun bound to the SCF promoter in chromatin immunoprecipitation assays. Mutation of the c-Jun binding site abolished c-Jun-mediated induction of the SCF promoter. These studies demonstrate an essential role of c-Jun in cellular migration through induction of SCF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.