ArticleMolecular and cellular biology2007
The natural osmolyte trehalose is a positive regulator of the heat-induced activity of yeast heat shock transcription factor.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 89 citations in OpenAlex.
- The root's hidden ally: How the rhizosheath microbiome fortifies crops against drought.aBIOTECH · 2026Review
- Enhancing water use efficiency and nutritional quality of maize fodder under deficit irrigation with microbial and potassium amendments.BMC plant biology · 2026Article
- Thermotolerant yeasts promoting climate-resilient bioproduction.FEMS yeast research · 2025Review
- Article
- The effect of CO2 concentration on yeast fermentation: rates, metabolic products, and yeast stress indicators.Journal of industrial microbiology & biotechnology · 2023Article
- Drought-tolerant Sphingobacterium changzhouense Alv associated with Aloe vera mediates drought tolerance in maize (Zea mays).World journal of microbiology & biotechnology · 2022Article
- ReporterSeq reveals genome-wide dynamic modulators of the heat shock response across diverse stressors.eLife · 2021Article
- Article
- Soluble Sugar and Lipid Readjustments in theMetabolites · 2019Article
- Article
- Artificial Fusion of mCherry Enhances Trehalose Transferase Solubility and Stability.Applied and environmental microbiology · 2019Article
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae.PloS one · 2019Article
- Protective role of trehalose during radiation and heavy metal stress in Aureobasidium subglaciale F134.Scientific reports · 2017Article
- Identifying protein kinase-specific effectors of the osmostress response in yeast.Science signaling · 2017Article
- Cross-stress resistance in Saccharomyces cerevisiae yeast--new insight into an old phenomenon.Cell stress & chaperones · 2016Review
- Yeast Tolerance to Various Stresses Relies on the Trehalose-6P Synthase (Tps1) Protein, Not on Trehalose.The Journal of biological chemistry · 2015Article
- Article
- Trends in bacterial trehalose metabolism and significant nodes of metabolic pathway in the direction of trehalose accumulation.Microbial biotechnology · 2013Review
- Identification and characterization of a novel trehalose synthase gene derived from saline-alkali soil metagenomes.PloS one · 2013Article
- Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans.The Journal of biological chemistry · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, the intracellular concentration of trehalose increases rapidly in response to many environmental stresses, including heat shock. These high trehalose levels have been correlated with tolerance to adverse conditions and led to the model that trehalose functions as a chemical cochaperone. Here, we show that the transcriptional activity of Hsf1 during the heat shock response depends on trehalose. Strains with low levels of trehalose have a diminished transcriptional response to heat shock, while strains with high levels of trehalose have an enhanced transcriptional response to heat shock. The enhanced transcriptional response does not require the other heat-responsive transcription factors Msn2/4 but is dependent upon heat and Hsf1. In addition, the phosphorylation levels of Hsf1 correlate with both transcriptional activity and the presence of trehalose. These in vivo results support a new role for trehalose, where trehalose directly modifies the dynamic range of Hsf1 activity and therefore influences heat shock protein mRNA levels in response to stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.