ArticleMolecular and cellular biology2007
Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Regulation of the immune system by the insulin receptor in health and disease.Frontiers in endocrinology · 2023Review
- Supplying the trip to antibody production-nutrients, signaling, and the programming of cellular metabolism in the mature B lineage.Cellular & molecular immunology · 2022Review
- Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.Scientific reports · 2018Article
- Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Review
- Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virus.Journal of virology · 2010Article
- Raf-independent, PP2A-dependent MEK activation in response to ERK silencing.Biochemical and biophysical research communications · 2009Article
- PLC-gamma2 is essential for formation and maintenance of memory B cells.The Journal of experimental medicine · 2009Article
- Article
- Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of extracellular signal-regulated protein kinase (ERK) has been implicated in proliferation as well as differentiation in a wide variety of cell types. Using B-cell-specific gene-targeted mice, we report here that in T-cell-dependent immune responses, ERK2 is required to generate efficient immunoglobulin G (IgG) production. In its absence, the proportion of antigen-specific surface IgG1-bearing cells and the subsequent number of IgG1 antibody-secreting cells were decreased, despite apparently unimpaired class switch recombination. Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.