Trial reportBMJ (Clinical research ed.)2007
Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00381537 (Prediction of Childhood Epilepsy Outcome in Bangladesh), which is not on this map. Cited by 19 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prediction of Childhood Epilepsy Outcome in Bangladesh
Who cites it
19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Levetiracetam versus carbamazepine monotherapy in the management of pediatric focal epilepsy: A systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2024Pooled it
- Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.The Cochrane database of systematic reviews · 2022Pooled it
- Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.The Cochrane database of systematic reviews · 2018Pooled it
- Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.The Cochrane database of systematic reviews · 2017Pooled it
- Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.The Cochrane database of systematic reviews · 2017Pooled it
- Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.The Cochrane database of systematic reviews · 2016Pooled it
- Phenobarbitone versus phenytoin monotherapy for epilepsy: an individual participant data review.The Cochrane database of systematic reviews · 2019Review
- Observational
- Epilepsy is ubiquitous, but more devastating in the poorer regions of the world... or is it?Epilepsia · 2014Article
- Clinical features, proximate causes, and consequences of active convulsive epilepsy in Africa.Epilepsia · 2014Article
- Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.BMC research notes · 2013Article
- Epilepsy and its effects on children and families in rural Uganda.African health sciences · 2013Article
- Behavioral problems in children with epilepsy in rural Kenya.Epilepsy & behavior : E&B · 2012Article
- Behavioural comorbidity in Tanzanian children with epilepsy: a community-based case-control study.Developmental medicine and child neurology · 2011Article
- Packages of care for epilepsy in low- and middle-income countries.PLoS medicine · 2009Article
- Epilepsy in the developing world.Current neurology and neuroscience reports · 2009Article
- Childhood epilepsy: Management in resource-limited setting.Annals of Indian Academy of Neurology · 2008Article
- Treatment of epilepsy in developing countries.BMJ (Clinical research ed.) · 2007Article
- A Comparative Study on the Efficacy of Levetiracetam and Carbamazepine in the Treatment of Rolandic Seizures in Children: An Open-Label Randomized Controlled Trial.Journal of research in pharmacy practiceArticle
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh.
designProspective randomised controlled single centre trial.
settingSpecialist children's hospital in Dhaka, Bangladesh.
participants108 children aged 2-15 with generalised tonic-clonic (n=51) or partial and secondary generalised seizures (n=57).
main outcome measuresSeizure control and behavioural side effects.
results91 children were followed up for 12 months. Six required a change of antiepilepsy drug. Side effects were compared in 85 children. In the last quarter of the 12 month follow-up, 71 children were seizure free after one year's treatment. Thirty two in the phenobarbital group and 39 in the carbamazepine group had no seizures in 74 and 102 days after randomisation, respectively. Ten children had increased behavioural problems, which were unacceptable in four (one in the phenobarbital group and three in the carbamazepine group). Independent t tests, however, showed no difference between the two trial drugs.
conclusionThere was no excess in behavioural side effects with phenobarbital in children with epilepsy in a country with limited resources. Trial registration NCT00381537.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.