ArticleJournal of virology1991
Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- Epitope-Based Vaccine Designing ofInternational journal of peptide research and therapeutics · 2020Article
- Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China.Virology journal · 2019Article
- Design, Immune Responses and Anti-Tumor Potential of an HPV16 E6E7 Multi-Epitope Vaccine.PloS one · 2015Article
- Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope.The Journal of biological chemistry · 2013Article
- Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers.Iranian journal of basic medical sciences · 2012Article
- Human papillomavirus type 16 E7 DNA vaccine: mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity.Journal of virology · 1999Article
- Predominant recognition of species-specific determinants of the GroES homologues from Mycobacterium leprae and M. tuberculosis.Immunology · 1998Article
- Immunogenicity of peptides for B cells is not impaired by overlapping T-cell epitope topology.Immunology · 1996Article
- T-cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia.Clinical and diagnostic laboratory immunology · 1996Article
- Antibodies to human papillomavirus type 16 E7 related to clinicopathological data in patients with cervical carcinoma.Journal of clinical pathology · 1995Article
- Pathogenesis of genital HPV infection.Genitourinary medicine · 1993Review
- Production and characterization of human proliferative T-cell clones specific for human papillomavirus type 1 E4 protein.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is strong evidence implicating human papillomavirus type 16 (HPV16) in the genesis of human genital cancer. Viral DNA has been identified in invasive carcinoma of the uterine cervix and in cell lines derived from cervical carcinomas. These sequences are actively transcribed, and translation products corresponding to the early (E)-region genes have been identified. The most abundant viral protein is the E7 protein, which has been shown to possess transforming activity for both established and primary cells. In addition, it has been shown to bind to a cellular tumor suppressor, the retinoblastoma gene product (pRb-105). In view of these properties, we have undertaken the immunological analysis of this protein and have identified four T-cell epitopes and three B-cell epitopes by using a series of overlapping peptides spanning the entire HPV16 E7 sequence. Two of the B-cell epitopes were recognized by antisera from mice with three different murine (H-2) haplotypes (k, d, and s) immunized with two different E7 fusion proteins and from Fischer rats seeded with baby rat kidney cells transformed by HPV16 E7 and ras. A third B-cell epitope was recognized by antisera from CBA mice seeded with HPV16 E7-expressing L cells. Two regions of the protein contain common B- and T-cell epitopes, one of which appears to be particularly immunodominant.
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