ArticleWorld journal of gastroenterology2006
Lactase non-persistence and milk consumption in Estonia.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis.International journal of epidemiology · 2016Pooled it
- Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.Nutrients · 2021Review
- Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study.Journal of the Canadian Association of Gastroenterology · 2020Article
- The Eurasian lactase persistence variantJournal of nutritional science · 2020Article
- Lactose Intolerance, Dairy Avoidance, and Treatment Options.Nutrients · 2018Review
- In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence.Annals of human genetics · 2016Article
- Tracing pastoralist migrations to southern Africa with lactase persistence alleles.Current biology : CB · 2014Article
- Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: the inflammatory bowel disease model.Clinical epidemiology · 2014Article
- Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease.Gut pathogens · 2012Article
- Lactose intolerance: diagnosis, genetic, and clinical factors.Clinical and experimental gastroenterology · 2012Article
- Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population.PloS one · 2012Article
- Lactase non-persistent genotype influences milk consumption and gastrointestinal symptoms in Northern Russians.BMC gastroenterology · 2011Article
- The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.Human genetics · 2011Article
- European lactase persistence genotype shows evidence of association with increase in body mass index.Human molecular genetics · 2010Article
- Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia.
methodsWe genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints.
resultsThe frequency of the genotype of the C/C-13910 (lactase non-persistence) was found to be 24.8% in native Estonians. No other single nucleotide polymorphisms covering the region of 400 bp adjacent to the C/T-13910 variant were found. Lactase non-persistence subjects were found to consume less milk than lactase persistence subjects.
conclusionThe frequency of lactase non-persistence defined by the C/C-13910 genotype confirms the results of the previous studies based on indirect methods of determining hypolactasia. Milk consumption of lactase non-persistence subjects is consistent with previously reported figures of adult-type hypolactasia in Estonia. However, lactase non-persistence does not prevent the intake of milk in many adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.