ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Brain gene expression differences related to ethanol preference in the collaborative cross founder strains.Frontiers in behavioral neuroscience · 2022Article
- On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption.Frontiers in psychiatry · 2021Review
- Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID).Alcohol (Fayetteville, N.Y.) · 2017Article
- The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Selection for drinking in the dark alters brain gene coexpression networks.Alcoholism, clinical and experimental research · 2013Article
- Article
- Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Gene networks and haloperidol-induced catalepsy.Genes, brain, and behavior · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Treatment- and population-dependent activity patterns of behavioral and expression QTLs.PloS one · 2012Article
- Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure.Frontiers in genetics · 2012Article
- Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays.PloS one · 2011Article
- Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.Genes, brain, and behavior · 2011Article
- Integrative analysis of low- and high-resolution eQTL.PloS one · 2010Article
- Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse.BMC genomics · 2010Article
- New outbred colony derived from Mus musculus castaneus to identify skin tumor susceptibility loci.Molecular carcinogenesis · 2010Article
- Article
- Replication and narrowing of gene expression quantitative trait loci using inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice.Psychopharmacology · 2009Article
- Genome and proteome annotation: organization, interpretation and integration.Journal of the Royal Society, Interface · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
We have completed whole-genome scans for quantitative trait loci (QTLs) associated with acute ethanol-induced activation in the six F(2) intercrosses that can be formed from the C57BL/6J (B6), DBA/2J (D2) , BALB/cJ (C), and LP/J (LP) inbred strains. The goal was to test the hypothesis that given the relatively simple structure of the laboratory mouse genome, the same QTLs will be detected in multiple crosses which in turn will provide support for the strategy of multiple-cross mapping (MCM). QTLs with LOD scores greater than 4 were detected on Chrs 1, 2, 3, 8, 9, 13, 14, and 16. Only for the QTL on distal Chr 1 was there convincing evidence that the same or at least a very similar QTL was detected in multiple crosses. We also mapped the Chr 2 QTL directly in heterogeneous stock (HS) animals derived from the four inbred strains. At G(19) the QTL was mapped to an approximately 3-Mbp interval and this interval was associated with a haplotype block with a largely biallelic structure: B6-L:C-D2. We conclude that mapping in HS animals not only provides significantly greater QTL resolution, at least in some cases it provides significantly more information about the QTL haplotype structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.